Laboratories: Bioinformatics. Svstems Biology, Clinical Informatics. Medical Image Analvsis, Optical Imaging. Animal Imaging and Molecular Imaging Laboratories of The Centerfor Biotechnology and Informatics (CBI). TMHRI and Research Department of Radiologv at Fondren/Brown Translation Research Laboratories The Fondren/Brown Translation Research Laboratories in the Methodist Research Institute are state-of-the-art flexible, open design, modular laboratories. The Fondren/Brown laboratories encompass approximately 80,000 square feet of """"""""wet"""""""" and """"""""dry"""""""" laboratory research space. Specifically, the 5th Floor (approximately 30,000 square feet) ofthe Fondren/Brown Building was renovated and will provide the support laboratory space for this grant. Over 4,000 square feet of this laboratory will be dedicated to Dr. Wong's bioinformatics and imaging research program and will be used for this grant proposal. The microscopy and molecular imaging lab. medical systems biology wet lab. research databases, in vitro molecular biology, chemistry, and proteomics experiments will be performed in this space. The laboratory space is bordered by support rooms including a linear equipment room, environmental rooms, tissue culture rooms, and specialized equipment/procedure rooms. Directly adjacent to the laboratory space is the Fondren vivarium that is used as a core facility. The proximity of this vivarium to Dr. Wong's laboratory offers ease of transport for animal related experiments as well as access to procedure rooms located within the vivarium itself. In addition, about 2,000 sq feet at the 7""""""""^ Floor ofthe Fondren/Brown Building houses the microscopy core lab of the high content screening microscopy system, confocal microscopy, and LCM (laser capture microscopy) as well as physics and medical instrumentation laboratory, both directed by Dr. Wong also. Another 4,000 sq feet at the 3^''floor of West Pavillion Building of The Methodist Hospital hosts the biomedical instrumentation and biomedical computing labs and a large dedicated conference room of Dr. Wong's Center of Biotechnology and Informatics Program.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Methodist Hospital Research Institute
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Neelakantan, Deepika; Zhou, Hengbo; Oliphant, Michael U J et al. (2017) EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells. Nat Commun 8:15773
Chen, Suyun; Ibrahim, Nuhad K; Yan, Yuanqing et al. (2017) Complete Metabolic Response on Interim 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography to Predict Long-Term Survival in Patients with Breast Cancer Undergoing Neoadjuvant Chemotherapy. Oncologist 22:526-534
Liang, Diana H; Choi, Dong Soon; Ensor, Joe E et al. (2016) The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair. Cancer Lett 376:249-58
Dong, J; Zhao, W; Shi, A et al. (2016) The PR status of the originating cell of ER/PR-negative mouse mammary tumors. Oncogene 35:4149-54
Dobrolecki, Lacey E; Airhart, Susie D; Alferez, Denis G et al. (2016) Patient-derived xenograft (PDX) models in basic and translational breast cancer research. Cancer Metastasis Rev 35:547-573
Tanei, Tomonori; Choi, Dong Soon; Rodriguez, Angel A et al. (2016) Antitumor activity of Cetuximab in combination with Ixabepilone on triple negative breast cancer stem cells. Breast Cancer Res 18:6
Yeung, Tsz-Lun; Leung, Cecilia S; Li, Fuhai et al. (2016) Targeting Stromal-Cancer Cell Crosstalk Networks in Ovarian Cancer Treatment. Biomolecules 6:3
Hein, S M; Haricharan, S; Johnston, A N et al. (2016) Luminal epithelial cells within the mammary gland can produce basal cells upon oncogenic stress. Oncogene 35:1461-7
Park, Jun Hyoung; Vithayathil, Sajna; Kumar, Santosh et al. (2016) Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer. Cell Rep 14:2154-2165
Zhao, Zhen; Zhu, Xiaoping; Cui, Kemi et al. (2016) In Vivo Visualization and Characterization of Epithelial-Mesenchymal Transition in Breast Tumors. Cancer Res 76:2094-2104

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