The Center of Cancer Systems Biology (CCSB) St. Elizabeth's Medical Center, Tufts Univ School of Med (TUSM), brings together diverse researchers from biological, mathematical, physical and clinical backgrounds to better understand the molecular and tissue-level events underlying cancer evolution and development. In the three years since its founding the CCSB has matured into a well-established, deeply interactive and multidisciplinary cancer group which it is becoming an internationally competitive research and training facility and research data repository in cancer systems biology Tufts CCSB has already been the recipient of two federally funded multidisciplinary Program Project Grants on carcinogenesis. Each combines mathematical and computational modeling with state-of the art experimental cancer biology. The first is a NASA Specialized Center of Research (NSCOR) funded to study risk of solid tumor carcinogenesis from space radiafion exposure ($10 Million;PI Dr. HIatky). The second is a DOE-funded center to study carcinogenesis risk following low-dose radiation exposure from background radiation ($7.5 million to Dr. HIatky and 1 million to Dr. Hahnfeldt for mathematical analysis of this issue). Clearly, both the PI and the Center are well-versed in running large program grants on carcinogenesis. Funding of this ICBP application would provide an opportunity to connect this established CCSB with the national networks of ICBP-funded Centers around the country also embarking on predictive cancer modeling and thereby contribute to the NCI directed goals of this Program. Nicolaos Madias, MD, Director of Medicine, SEMC, TUSM made deliberate strategic decisions in establishing the CCSB, recruiting Dr. HIatky as director, and the dedication of laboratory research space and computing resources, as well as the subsequent expansion of her group, represents a major institutional investment and continuing commitment to innovative, cuffing edge cancer research. SEMC has backed up this research commitment with a massive expansion plan being implemented for its clinical services at the Oncology Center, involving an additional 8,000 sq ft for Rad One and an additional 8,000 sq ft for Medical Oncology (see support letter Dr. Madias). The breadth and depth of SEMC's commitment to this long-term strategic set of goals is clear. The continuing strength of the intellectual, academic, and training environment is reinforced by Research faculty as well as clinical training appointments through TUSM.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA149233-04
Application #
8536737
Study Section
Special Emphasis Panel (ZCA1-SRLB-C)
Project Start
Project End
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
4
Fiscal Year
2013
Total Cost
$932,405
Indirect Cost
$426,874
Name
Genesys Research Institute, Inc.
Department
Type
DUNS #
965467512
City
Boston
State
MA
Country
United States
Zip Code
02135
Radivoyevitch, Tomas; Jankovic, Gradimir M; Tiu, Ramon V et al. (2014) Sex differences in the incidence of chronic myeloid leukemia. Radiat Environ Biophys 53:55-63
Weekes, Suzanne L; Barker, Brian; Bober, Sarah et al. (2014) A multicompartment mathematical model of cancer stem cell-driven tumor growth dynamics. Bull Math Biol 76:1762-82
Nguyen, David H; Ouyang, Haoxu; Mao, Jian-Hua et al. (2014) Distinct luminal-type mammary carcinomas arise from orthotopic Trp53-null mammary transplantation of juvenile versus adult mice. Cancer Res 74:7149-58
Benzekry, S├ębastien; Lamont, Clare; Beheshti, Afshin et al. (2014) Classical mathematical models for description and prediction of experimental tumor growth. PLoS Comput Biol 10:e1003800
Benzekry, S├ębastien; Gandolfi, Alberto; Hahnfeldt, Philip (2014) Global dormancy of metastases due to systemic inhibition of angiogenesis. PLoS One 9:e84249
Beheshti, Afshin; Peluso, Michael; Lamont, Clare et al. (2014) Proton irradiation augments the suppression of tumor progression observed with advanced age. Radiat Res 181:272-83
Gale, Robert Peter; Hlatky, Lynn; Sachs, Rainer K et al. (2014) Why is there so much therapy-related AML and MDS and so little therapy-related CML? Leuk Res 38:1162-4
Poleszczuk, J; Hahnfeldt, P; Enderling, H (2014) Biphasic modulation of cancer stem cell-driven solid tumour dynamics in response to reactivated replicative senescence. Cell Prolif 47:267-76
Prochazka, Vaclav; Klosova, Hana; Stetinsky, Jiri et al. (2014) Addition of platelet concentrate to dermo-epidermal skin graft in deep burn trauma reduces scarring and need for revision surgeries. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 158:242-58
Hlatky, Lynn; Hahnfeldt, Philip (2014) Beyond the cancer cell: progression-level determinants highlight the multiscale nature of carcinogenesis risk. Cancer Res 74:659-64

Showing the most recent 10 out of 27 publications