PROJECT 4/GAMBHIR PI: Gambhlr, Sanjiv S N3.4.1. Project Summary. Our long-term goals are to clinically translate nanodiagnostics {in vitro and in vivo) for the improved management of cancer patients. Our primary focus for this competing GONE renewal is on developing and using nanotechnology for earlier cancer detection/intervention, and for monitoring response to anti-neoplastic therapy. In the current proposal we focus on both ovarian and non-small cell lung cancers but expect that our strategies will eventually apply to many other cancers. We have made significant progress over the last cycle of this CCNE competing renewal grant including the development of Raman and photoacoustic molecular imaging strategies. In the last year we have also pursued translation of gold based Raman nanoparticles with endoscopic imaging for earlier colorectal cancer detection in patients. Both in vitro nanosensors and in vivo nano-molecular imaging will be utilized to accomplish our long-term goals. The combination of both in vitro and in vivo diagnostic strategies is expected to lead to a much greater accuracy and cost-effectiveness than either strategy alone. To translate our in vitro and in vivo diagnostic strategies we will utilize mouse models of human cancer that help us to test our approaches prior to clinical translation. The clinical translation will be accomplished through the help ofthe clinical translation core (Core 3) which links to various clinical trials and leverages on other funding mechanisms already in place in our CCNE.
Two aims focused on ovarian and non-small cell lung cancer diagnostics will be pursued to accomplish our goals and are detailed next (Fig. N3.4.1).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA151459-04
Application #
8540378
Study Section
Special Emphasis Panel (ZCA1-GRB-S)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2013
Total Cost
$156,925
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Pu, Kanyi; Shuhendler, Adam J; Valta, Maija P et al. (2014) Phosphorylcholine-coated semiconducting polymer nanoparticles as rapid and efficient labeling agents for in vivo cell tracking. Adv Healthc Mater 3:1292-8
Hudak, Carolyn S; Gulyaeva, Olga; Wang, Yuhui et al. (2014) Pref-1 marks very early mesenchymal precursors required for adipose tissue development and expansion. Cell Rep 8:678-87
Cheng, Kai; Kothapalli, Sri-Rajasekhar; Liu, Hongguang et al. (2014) Construction and validation of nano gold tripods for molecular imaging of living subjects. J Am Chem Soc 136:3560-71
Zhang, Mingliang; Bechstein, Daniel J B; Wilson, Robert J et al. (2014) Wafer-scale synthesis of monodisperse synthetic magnetic multilayer nanorods. Nano Lett 14:333-8
Sinclair, Robert; Kempen, Paul Joseph; Chin, Richard et al. (2014) The Stanford Nanocharacterization Laboratory (SNL) and Recent Applications of an Aberration-Corrected Environmental Transmission Electron Microscope. Adv Eng Mater 16:476-481
Dimov, Ivan K; Lu, Rong; Lee, Eric P et al. (2014) Discriminating cellular heterogeneity using microwell-based RNA cytometry. Nat Commun 5:3451
Pu, Kanyi; Shuhendler, Adam J; Jokerst, Jesse V et al. (2014) Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice. Nat Nanotechnol 9:233-9
Sasportas, Laura Sarah; Gambhir, Sanjiv Sam (2014) Imaging circulating tumor cells in freely moving awake small animals using a miniaturized intravital microscope. PLoS One 9:e86759
Park, Seung-Min; Sabour, Andrew F; Son, Jun Ho et al. (2014) Toward integrated molecular diagnostic system (i MDx): principles and applications. IEEE Trans Biomed Eng 61:1506-21
Wang, Jianbin; Quake, Stephen R (2014) RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection. Proc Natl Acad Sci U S A 111:13157-62

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