The Dartmouth CCNE (DCCNE) Education/Training Program complements the research effort by focusing on the development of a graduate experience, which links together nanotechnology and engineering with cancer biology and immunology. This cross-disciplinary Program uses a cross-departmental organizafion to teach the fundamental scientific bases of materials, imaging systems, therapy technologies, immunology and toxicology, and specifically, their applicafion to cancer nanomedicine. The Program sets quanfifiable, achievable goals in terms of publications, conference attendance and seminars attended, to help set metrics for career development among students, post-docs, and established investigators. The key emphasis is to develop strategic partnerships formed from multidisciplinary teams with complementary expertise sets and then to match the learning goals of the participants to their individual training programs. This is possible because cancer nanotechnology research at Dartmouth occurs in graduate programs that are already delocalized from departments, evident at Thayer School of Engineering and at Dartmouth Medical School. A specific curriculum is proposed;students choose three of six possible areas of study, of which at least one must be each from engineering and medicine. Attention is given to research mentoring and career development The DCCNE will evaluate Program quality and efficiency at defined points on the education/training timeline, and will use the resulting outcomes information to inform ongoing programmatic development. Mechanisms for exchange of trainees among participafing CCNEs is planned through a monthly seminar series featuring speakers from across the country, particulariy from other CCNEs and nanotechnology research hubs. Outreach efforts will include seminars and symposia to disseminate DCCNE research in the wider scientific community, organizafion of and participation in national and regional conferences, and weekly seminars at Dartmouth focused on cancer nanotechnology. The DCCNE will hold an annual half-day forum at the Cancer Center to engage invited presentations in clinical translational research in nanotechnology as well as DCCNE investigators.

Public Health Relevance

The DCCNE Education/Training and Outreach Program complements the research effort by focusing on the development of a graduate experience linking nanostructures with cancer biology. It is organized as an extra-departmental program to develop and teach the fundamental scientific bases of nanostructures, cancer biology, and, specifically, applicafion to new and emerging treatments in nanomedicine.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA151662-03
Application #
8379368
Study Section
Special Emphasis Panel (ZCA1-GRB-S)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
3
Fiscal Year
2012
Total Cost
$128,218
Indirect Cost
$83,027
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Hoopes, P Jack; Wagner, Robert J; Duval, Kayla et al. (2018) Treatment of Canine Oral Melanoma with Nanotechnology-Based Immunotherapy and Radiation. Mol Pharm 15:3717-3722
Pearce, John A; Petryk, Alicia A; Hoopes, P Jack (2017) Numerical Model Study of In Vivo Magnetic Nanoparticle Tumor Heating. IEEE Trans Biomed Eng 64:2813-2823
Fang, Yongliang; Chu, Thach H; Ackerman, Margaret E et al. (2017) Going native: Direct high throughput screening of secreted full-length IgG antibodies against cell membrane proteins. MAbs 9:1253-1261
Hoopes, P Jack; Wagner, Robert J; Song, Ailin et al. (2017) The effect of hypofractionated radiation and magnetic nanoparticle hyperthermia on tumor immunogenicity and overall treatment response. Proc SPIE Int Soc Opt Eng 10066:
Hoopes, P Jack; Moodie, Karen L; Petryk, Alicia A et al. (2017) Hypo-fractionated Radiation, Magnetic Nanoparticle Hyperthermia and a Viral Immunotherapy Treatment of Spontaneous Canine Cancer. Proc SPIE Int Soc Opt Eng 10066:
Ficko, Bradley W; NDong, Christian; Giacometti, Paolo et al. (2017) A Feasibility Study of Nonlinear Spectroscopic Measurement of Magnetic Nanoparticles Targeted to Cancer Cells. IEEE Trans Biomed Eng 64:972-979
Hoopes, P Jack; Mazur, Courtney M; Osterberg, Bjorn et al. (2017) Effect of intra-tumoral magnetic nanoparticle hyperthermia and viral nanoparticle immunogenicity on primary and metastatic cancer. Proc SPIE Int Soc Opt Eng 10066:
Davis, Scott C; Tichauer, Kenneth M (2016) Small-Animal Imaging Using Diffuse Fluorescence Tomography. Methods Mol Biol 1444:123-37
Reeves, Daniel B; Shi, Yipeng; Weaver, John B (2016) Generalized Scaling and the Master Variable for Brownian Magnetic Nanoparticle Dynamics. PLoS One 11:e0150856
Stigliano, Robert V; Shubitidze, Fridon; Petryk, James D et al. (2016) Mitigation of eddy current heating during magnetic nanoparticle hyperthermia therapy. Int J Hyperthermia 32:735-48

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