CORE TITLE: Nanoengineering Core CORE SUMMARY: The Multi-Stage Vectors (MSV), mesoporous silicon particles, serve as an 'integrator', and vectoring function for single types and multiple-type combinations of the nanoparticles. The MSVs are present in all TCCN projects. MSVs are manufactured using photolithographic and electrochemical methods developed by the Ferrari group in a National nanotechnology core facility at the University of Texas in Austin, where Dr. Ferrari maintains a team of 12 personnel coordinated by TCCN investigator Assistant Professor Xuewu Liu. The manufacture of MSVs involves highly specialized equipment and very complex multi-step protocols. Therefore, it is necessary to establish the mesoporous silicon-producing operation ofthe TCCN as a Nanoengineering Core, directed by Dr. Ferrari, in collaboration with Dr. West for what pertains to the integration of second-stage nanoparticles in the MSVs, and Dr. Liu. In addition to the particulate systems, the Nanoengineering Core will manufacture and characterize the mesoporous silica nanochips for proteomics and peptidomlcs, which are utilized in all TCCN projects for the monitoring of therapeutic and preventative efficacy, and the identification of multi-molecular signature markers for the early detection of ovarian and pancreatic cancer. These nanochips were also developed by the Ferrari group in the National nanotechnology core facility in Austin.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA151668-05
Application #
8735870
Study Section
Special Emphasis Panel (ZCA1-GRB-S)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
5
Fiscal Year
2014
Total Cost
$156,291
Indirect Cost
$36,084
Name
University of Texas Health Science Center Houston
Department
Type
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225
Cui, Min-Hui; Branch, Craig A; Cahill, Sean M et al. (2015) In vivo proton MR spectroscopy of pancreatic neuroendocrine tumors in a multiple endocrine neoplasia type 1 conditional knockout mouse model. Magn Reson Med 74:1221-6
Bottsford-Miller, Justin; Choi, Hyun-Jin; Dalton, Heather J et al. (2015) Differential platelet levels affect response to taxane-based therapy in ovarian cancer. Clin Cancer Res 21:602-10
Sun, Yan; Hu, Limei; Zheng, Hong et al. (2015) MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer. J Pathol 235:25-36
Wen, Yunfei; Graybill, Whitney S; Previs, Rebecca A et al. (2015) Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer. Clin Cancer Res 21:448-59
Previs, Rebecca A; Coleman, Robert L; Harris, Adrian L et al. (2015) Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer. Clin Cancer Res 21:955-61
Jaganathan, Hamsa; Mitra, Sucharita; Srinivasan, Srimeenakshi et al. (2014) Design and in vitro evaluation of layer by layer siRNA nanovectors targeting breast tumor initiating cells. PLoS One 9:e91986
Ozpolat, Bulent; Sood, Anil K; Lopez-Berestein, Gabriel (2014) Liposomal siRNA nanocarriers for cancer therapy. Adv Drug Deliv Rev 66:110-6
Yang, Yong; Wolfram, Joy; Fang, Xiaohong et al. (2014) Polyarginine induces an antitumor immune response through binding to toll-like receptor 4. Small 10:1250-4
Tang, Lei; van de Ven, Anne L; Guo, Dongmin et al. (2014) Computational modeling of 3D tumor growth and angiogenesis for chemotherapy evaluation. PLoS One 9:e83962
Zhaorigetu, Siqin; Rodriguez-Aguayo, Cristian; Sood, Anil K et al. (2014) Delivery of negatively charged liposomes into the atherosclerotic plaque of apolipoprotein E-deficient mouse aortic tissue. J Liposome Res 24:182-90

Showing the most recent 10 out of 153 publications