Curcumin, a yellow polyphenol compound found in the Indian spice turmeric (Curcuma longa) demonstrates potent anti-cancer effects against a wide variety of human tumor models in preclinical studies. A major pitfall forthe application of curcumin to human cancer therapy has been its limited systemic bioavailability, such that the few clinical trials conducted so far had administered

Public Health Relevance

The clinical translafion of the promising anti-cancer agent curcumin has been hampered due to poor absorpfion from the gut. We have generated a nanocurcumin formulation that, for the first time, bypasses this major pitfall, and has the potenfial to enable widespread application of curcumin to cancer therapy. The studies proposed herein are focused on generating the efficacy and toxicity required to begin clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA151838-04
Application #
8545549
Study Section
Special Emphasis Panel (ZCA1-GRB-S)
Project Start
2013-09-13
Project End
2015-07-31
Budget Start
2013-09-13
Budget End
2014-07-31
Support Year
4
Fiscal Year
2013
Total Cost
$230,177
Indirect Cost
$105,001
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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