The Bioinformatics Core Facility at Northwestern University's Center of Cancer Nanotechnology Excellence (NU-CCNE) consists of an established multi-disciplinary team of more than twenty computational biologists, bloinformaticists and IT specialists whose activities include a broad range of clinical and basic science informatics and bioinformatics activities that are directly relevant to the mission and goals of the CCNE. The team has a track record of participating in and coordinating with national alliances, such as the caBlG project led by the NCI CBI IT. All Core Facility members are faculty or staff in the Robert H. Lurie Comprehensive Cancer Center at Northwestern University Feinberg School of Medicine with three faculty, Du, Kibbe and Lin, also having appointments in the NU Clinical and Translational Sciences Institute (NUCATS).
The specific aims of the Core are to: 1. Support NU-CCNE Investigators with bioinformatics services and educational opportunities. 2. Provide data sharing and the capacity to link with the NCI Center for Bioinformatics. 3. Coordinate bioinformatics resources and efforts at Northwestern and across the CCNE Alliance. Over the next five years, the Core will continue to provide the NU-CCNE members with bioinformatics and computational support for molecular imaging, genomics, proteomics, clinical trials and clinical informatics. State of the art algorithms for pathway analysis, microarray analysis, proteomics, good software development practices, and data handling and computational resources will be available to NUCCNE members. These activities include applying the Cancer Center's clinical trials and translational informatics infrastructure to new drug and device trials emerging from the CCNE;profiling and unraveling the molecular targets and effects of CCNE-developed compounds by high throughput -omic techniques;integrating clinical data from the Northwestern Medidne Enterprise Data Warehouse to the clinical research activities of the CCNE;and applying caNanoLab in support of the activities of the CCNE. In addition, the Bioinformatics Core Facility will continue to respond to user requests for participation in grant applications, expand faculty and staff effort as needed to respond to the changing needs of funded grants, and strive to maintain the professional level of faculty and staff through their attendance at and participation in technical courses, training, and interaction with faculty throughout the institution and the world at conferences and meetings.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-GRB-S)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Northwestern University at Chicago
United States
Zip Code
Calabrese, Colin M; Merkel, Timothy J; Briley, William E et al. (2015) Biocompatible infinite-coordination-polymer nanoparticle-nucleic-acid conjugates for antisense gene regulation. Angew Chem Int Ed Engl 54:476-80
Chinen, Alyssa B; Guan, Chenxia M; Mirkin, Chad A (2015) Spherical nucleic acid nanoparticle conjugates enhance G-quadruplex formation and increase serum protein interactions. Angew Chem Int Ed Engl 54:527-31
Rubert Pérez, Charles M; Stephanopoulos, Nicholas; Sur, Shantanu et al. (2015) The powerful functions of peptide-based bioactive matrices for regenerative medicine. Ann Biomed Eng 43:501-14
Xi, Guifa; Robinson, Erik; Mania-Farnell, Barbara et al. (2014) Convection-enhanced delivery of nanodiamond drug delivery platforms for intracranial tumor treatment. Nanomedicine 10:381-91
Heffern, Marie C; Matosziuk, Lauren M; Meade, Thomas J (2014) Lanthanide probes for bioresponsive imaging. Chem Rev 114:4496-539
Moyer, Tyson J; Finbloom, Joel A; Chen, Feng et al. (2014) pH and amphiphilic structure direct supramolecular behavior in biofunctional assemblies. J Am Chem Soc 136:14746-52
Kuhn, Misty L; Zemaitaitis, Bozena; Hu, Linda I et al. (2014) Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylation. PLoS One 9:e94816
Kurepa, Jasmina; Nakabayashi, Ryo; Paunesku, Tatjana et al. (2014) Direct isolation of flavonoids from plants using ultra-small anatase TiOýýý nanoparticles. Plant J 77:443-53
Cabezas, Maria D; Eichelsdoerfer, Daniel J; Brown, Keith A et al. (2014) Combinatorial screening of mesenchymal stem cell adhesion and differentiation using polymer pen lithography. Methods Cell Biol 119:261-76
Shabbir, Shagufta H; Cleland, Megan M; Goldman, Robert D et al. (2014) Geometric control of vimentin intermediate filaments. Biomaterials 35:1359-66

Showing the most recent 10 out of 75 publications