The Bioinformatics Core Facility at Northwestern University's Center of Cancer Nanotechnology Excellence (NU-CCNE) consists of an established multi-disciplinary team of more than twenty computational biologists, bloinformaticists and IT specialists whose activities include a broad range of clinical and basic science informatics and bioinformatics activities that are directly relevant to the mission and goals of the CCNE. The team has a track record of participating in and coordinating with national alliances, such as the caBlG project led by the NCI CBI IT. All Core Facility members are faculty or staff in the Robert H. Lurie Comprehensive Cancer Center at Northwestern University Feinberg School of Medicine with three faculty, Du, Kibbe and Lin, also having appointments in the NU Clinical and Translational Sciences Institute (NUCATS).
The specific aims of the Core are to: 1. Support NU-CCNE Investigators with bioinformatics services and educational opportunities. 2. Provide data sharing and the capacity to link with the NCI Center for Bioinformatics. 3. Coordinate bioinformatics resources and efforts at Northwestern and across the CCNE Alliance. Over the next five years, the Core will continue to provide the NU-CCNE members with bioinformatics and computational support for molecular imaging, genomics, proteomics, clinical trials and clinical informatics. State of the art algorithms for pathway analysis, microarray analysis, proteomics, good software development practices, and data handling and computational resources will be available to NUCCNE members. These activities include applying the Cancer Center's clinical trials and translational informatics infrastructure to new drug and device trials emerging from the CCNE;profiling and unraveling the molecular targets and effects of CCNE-developed compounds by high throughput -omic techniques;integrating clinical data from the Northwestern Medidne Enterprise Data Warehouse to the clinical research activities of the CCNE;and applying caNanoLab in support of the activities of the CCNE. In addition, the Bioinformatics Core Facility will continue to respond to user requests for participation in grant applications, expand faculty and staff effort as needed to respond to the changing needs of funded grants, and strive to maintain the professional level of faculty and staff through their attendance at and participation in technical courses, training, and interaction with faculty throughout the institution and the world at conferences and meetings.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54CA151880-04S1
Application #
8710089
Study Section
Special Emphasis Panel (ZCA1-GRB-S)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2013
Total Cost
$5,397
Indirect Cost
$1,494
Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Hong, Bong Jin; Iscen, Aysenur; Chipre, Anthony J et al. (2018) Highly Stable, Ultrasmall Polymer-Grafted Nanobins (usPGNs) with Stimuli-Responsive Capability. J Phys Chem Lett 9:1133-1139
Zavaleta, Cristina; Ho, Dean; Chung, Eun Ji (2018) Theranostic Nanoparticles for Tracking and Monitoring Disease State. SLAS Technol 23:281-293
Sato, Kohei; Hendricks, Mark P; Palmer, Liam C et al. (2018) Peptide supramolecular materials for therapeutics. Chem Soc Rev 47:7539-7551
Rotz, Matthew W; Holbrook, Robert J; MacRenaris, Keith W et al. (2018) A Markedly Improved Synthetic Approach for the Preparation of Multifunctional Au-DNA Nanoparticle Conjugates Modified with Optical and MR Imaging Probes. Bioconjug Chem 29:3544-3549
Lilley, Laura M; Du, Kang; Krzyaniak, Matthew D et al. (2018) Effect of Magnetic Coupling on Water Proton Relaxivity in a Series of Transition Metal GdIII Complexes. Inorg Chem 57:5810-5819
Rink, Jonathan S; Yang, Shuo; Cen, Osman et al. (2017) Rational Targeting of Cellular Cholesterol in Diffuse Large B-Cell Lymphoma (DLBCL) Enabled by Functional Lipoprotein Nanoparticles: A Therapeutic Strategy Dependent on Cell of Origin. Mol Pharm 14:4042-4051
McMahon, Kaylin M; Scielzo, Cristina; Angeloni, Nicholas L et al. (2017) Synthetic high-density lipoproteins as targeted monotherapy for chronic lymphocytic leukemia. Oncotarget 8:11219-11227
Rammohan, Nikhil; Holbrook, Robert J; Rotz, Matthew W et al. (2017) Gd(III)-Gold Nanoconjugates Provide Remarkable Cell Labeling for High Field Magnetic Resonance Imaging. Bioconjug Chem 28:153-160
Scott, Alexander W; Garimella, Viswanadham; Calabrese, Colin M et al. (2017) Universal Biotin-PEG-Linked Gold Nanoparticle Probes for the Simultaneous Detection of Nucleic Acids and Proteins. Bioconjug Chem 28:203-211
Hung, Andy H; Lilley, Laura M; Hu, Fengqin et al. (2017) Magnetic barcode imaging for contrast agents. Magn Reson Med 77:970-978

Showing the most recent 10 out of 223 publications