The main objective of this project is to develop new theranostic probes that exploit the rapidly advancing field of nanotechnology. We will utilize the extraordinary magnetic properties of nanostructures for simultaneous imaging and treatment of cancer. Further, our bioactivated probes can be used for imaging cell fate and migration, gene expression, and secondary messenger activation in vivo. The rationale for this approach is that noninvasive molecular imaging is ideal for correlating the status of the tumor to treatment efficacy. Molecular imaging is an important tool for biological sciences and the clinical areas. In order to maximize the impact of these techniques, sensitive contrast agents must be developed that are also functional. We have demonstrated the ability of bioactivated MR contrast agents to act as in vivo biochemical reporters. Our project design is to use bioactivated probes attached to magnetic nanostructure (MNS) platforms for reporting on physiological properties of lesions and tumors. Imaging the MNS in conjunction with cancer treatments over time, we will be able to evaluate the molecular response of the cancer to the therapeutic. We have assembled a team of investigators whose specialties include synthetic and materials chemistry, nanostructure preparation, molecular imaging and oncology. Four graduate students of all levels with experience in at least one of these areas (molecular imaging, synthetic chemistry, nanostructure preparation) will be trained during the five years of funding supplied by this grant.
Pancreatic cancer and cancers of the central nervous system are associated with the worst prognoses of all cancers. The high rates of mortality are attributed to resistance of tumors towards therapeutics and physiological barriers. Clinicians need a straightforward way of evaluating treatment efficacy. Our goal is to improve treatments by providing a nonivasive way to monitor the effects of therapeutics overtime.
|Calabrese, Colin M; Merkel, Timothy J; Briley, William E et al. (2015) Biocompatible infinite-coordination-polymer nanoparticle-nucleic-acid conjugates for antisense gene regulation. Angew Chem Int Ed Engl 54:476-80|
|Chinen, Alyssa B; Guan, Chenxia M; Mirkin, Chad A (2015) Spherical nucleic acid nanoparticle conjugates enhance G-quadruplex formation and increase serum protein interactions. Angew Chem Int Ed Engl 54:527-31|
|Rubert Pérez, Charles M; Stephanopoulos, Nicholas; Sur, Shantanu et al. (2015) The powerful functions of peptide-based bioactive matrices for regenerative medicine. Ann Biomed Eng 43:501-14|
|Xi, Guifa; Robinson, Erik; Mania-Farnell, Barbara et al. (2014) Convection-enhanced delivery of nanodiamond drug delivery platforms for intracranial tumor treatment. Nanomedicine 10:381-91|
|Heffern, Marie C; Matosziuk, Lauren M; Meade, Thomas J (2014) Lanthanide probes for bioresponsive imaging. Chem Rev 114:4496-539|
|Moyer, Tyson J; Finbloom, Joel A; Chen, Feng et al. (2014) pH and amphiphilic structure direct supramolecular behavior in biofunctional assemblies. J Am Chem Soc 136:14746-52|
|Kuhn, Misty L; Zemaitaitis, Bozena; Hu, Linda I et al. (2014) Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylation. PLoS One 9:e94816|
|Kurepa, Jasmina; Nakabayashi, Ryo; Paunesku, Tatjana et al. (2014) Direct isolation of flavonoids from plants using ultra-small anatase TiOýýý nanoparticles. Plant J 77:443-53|
|Cabezas, Maria D; Eichelsdoerfer, Daniel J; Brown, Keith A et al. (2014) Combinatorial screening of mesenchymal stem cell adhesion and differentiation using polymer pen lithography. Methods Cell Biol 119:261-76|
|Shabbir, Shagufta H; Cleland, Megan M; Goldman, Robert D et al. (2014) Geometric control of vimentin intermediate filaments. Biomaterials 35:1359-66|
Showing the most recent 10 out of 75 publications