The long-term objective of this project is to bring to clinical practice a novel technology for the real-time and non-invasive measurement of cancer-related analytes. This technology consists of a sensor implanted at the time of a tumor biopsy to allow subsequent monitoring of tumor analytes such as pH and p02 through magnetic resonance methods.
The specific aims of the project are as follows: design and execute preclinical studies in support of a Premarl
Existing technology that assesses cancer treatment efficacy is cumbersome, costly and in the case of pH and p02, highly invasive. Approval ofthe pH and p02 sensors for commercialization will not only improve clinical care by providing the oncologist with a real-time and non-invasive monitoring tool, but will allow the development of a versatile technological platform capable of detecting any analyte with the appropriate sensing agent.
|Kamaly, Nazila; Fredman, Gabrielle; Fojas, Jhalique Jane R et al. (2016) Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis. ACS Nano 10:5280-92|
|Kamaly, Nazila; Yameen, Basit; Wu, Jun et al. (2016) Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release. Chem Rev 116:2602-63|
|Chertok, Beata; Langer, Robert; Anderson, Daniel G (2016) Spatial Control of Gene Expression by Nanocarriers Using Heparin Masking and Ultrasound-Targeted Microbubble Destruction. ACS Nano 10:7267-78|
|Liu, Yanlan; Gunda, Viswanath; Zhu, Xi et al. (2016) Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer. Proc Natl Acad Sci U S A 113:7750-5|
|Xu, Xiaoding; Wu, Jun; Liu, Yanlan et al. (2016) Ultra-pH-Responsive and Tumor-Penetrating Nanoplatform for Targeted siRNA Delivery with Robust Anti-Cancer Efficacy. Angew Chem Int Ed Engl 55:7091-4|
|Vegas, Arturo J; Veiseh, Omid; Doloff, Joshua C et al. (2016) Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol 34:345-52|
|Yu, Mikyung; Wu, Jun; Shi, Jinjun et al. (2016) Nanotechnology for protein delivery: Overview and perspectives. J Control Release 240:24-37|
|Yin, Hao; Song, Chun-Qing; Dorkin, Joseph R et al. (2016) Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo. Nat Biotechnol 34:328-33|
|Dang, Xiangnan; Gu, Li; Qi, Jifa et al. (2016) Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer. Proc Natl Acad Sci U S A 113:5179-84|
|Cui, Jian; Beyler, Andrew P; Coropceanu, Igor et al. (2016) Evolution of the Single-Nanocrystal Photoluminescence Linewidth with Size and Shell: Implications for Exciton-Phonon Coupling and the Optimization of Spectral Linewidths. Nano Lett 16:289-96|
Showing the most recent 10 out of 146 publications