The Bioinformatics Core will facilitate and enhance research into length and quality of life among breast cancer survivors conducted at the Penn TREC Survivor Center by providing expert experimental design and data analysis capabilities, as well as data management support and data sharing capabilities, to project study teams. The Core will coordinate and manage statistical design and analysis plans by providing access to quantitative consultation and support;provide statistical expertise in the design of experiments and studies, including research proposal development, sample size determination, randomization procedures, and plans for interim reviews and final analysis;perform statistical analyses and data exploration for project investigators using appropriate statistical and computing methodologies and assist in the interpretation and presentation of results;and assist with manuscript preparation, notably the writing of statistical and design components. The Core will also provide computerized tools that create customizable templates to allow tracking of study participants;undertake secure data entry procedures that ensure quality and protect identifiable health information;facilitate the storage and retrieval of data generated in the proposed research by creating and maintaining relational databases that provide access to common resources and information;ensure the accuracy ofthe data maintained in the databases by software-based data consistency and quality control systems;organize and maintain the databases to maximize accuracy and accessibility while maintaining strict confidentiality;generate analysis data sets and conduct quality control;and ensure timely and compatible submission of data sets and resources to the TREC Coordination Center. Core faculty and staff have the breadth and depth of expertise necessary to successfully contribute to the proposed research and will work within the structures described to effectively collaborate both within the Core and across the project teams to create a synergistic and efficient intellectual and technical resource.

Public Health Relevance

Statistics provides a foundation forthe design, conduct and analysis of experiments and studies based on data subject to random variation. The investigations proposed here require expertise in clinical trial design, management, and analysis;the personnel and resources described in this proposal will provide this expertise. The core will ensure the high quality of analytic and technical activities and contribute meaningfully to the stjccessful achievement of the Penn TREC Survivor Center aims and goals

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-4)
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University of Pennsylvania
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Brown, Justin C; Kumar, Anagha; Cheville, Andrea L et al. (2015) Association between lymphedema self-care adherence and lymphedema outcomes among women with breast cancer-related lymphedema. Am J Phys Med Rehabil 94:288-96
Sturgeon, Kathleen; Schadler, Keri; Muthukumaran, Geetha et al. (2014) Concomitant low-dose doxorubicin treatment and exercise. Am J Physiol Regul Integr Comp Physiol 307:R685-92
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Brown, Justin C; Lin, Lilie L; Segal, Saya et al. (2014) Physical activity, daily walking, and lower limb lymphedema associate with physical function among uterine cancer survivors. Support Care Cancer 22:3017-25
Hammer, Sean M; Brown, Justin C; Segal, Saya et al. (2014) Cancer-related impairments influence physical activity in uterine cancer survivors. Med Sci Sports Exerc 46:2195-201
James, Peter; Berrigan, David; Hart, Jaime E et al. (2014) Effects of buffer size and shape on associations between the built environment and energy balance. Health Place 27:162-70
Brown, Justin C; Mao, Jun J; Stricker, Carrie et al. (2014) Aromatase inhibitor associated musculoskeletal symptoms are associated with reduced physical activity among breast cancer survivors. Breast J 20:22-8
Brown, Justin C; Cheville, Andrea L; Tchou, Julia C et al. (2014) Prescription and adherence to lymphedema self-care modalities among women with breast cancer-related lymphedema. Support Care Cancer 22:135-43
Schmitz, Kathryn H; Neuhouser, Marian L; Agurs-Collins, Tanya et al. (2013) Impact of obesity on cancer survivorship and the potential relevance of race and ethnicity. J Natl Cancer Inst 105:1344-54

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