African Americans carry the highest cancer burden of any racial or ethnic group in the United States. A variety of factors (social, economic, genetic, nutritional and behavioral) contribute to the high rate of incidence and mortality among African Americans, and sorting out the contributions of each will require substantial and sustained research effort. Participation by members of the African American community in all aspects of cancer research is crucial to the success of this endeavor. The partnership between North Carolina Central University (NCCU) and the UNC-Chapel Hill Lineberger Comprehensive Cancer Center (UNCCH/LCCC), previously funded through a U56 award, has laid the groundwork for an inter-institutional training program for undergraduate students who are motivated to pursue careers in basic cancer research and in public health. This proposal requests support for the establishment of a unique 2 year program, called "Partners", designed to meet our goal of increasing the number of undergraduate students from both NCCU and UNC-Chapel Hill who successfully pursue careers devoted to finding causes, cures, and prevention strategies for cancers that disproportionately affect minorities, particularly African Americans.
The Specific Aims ofthe Partners Program are as follows: (1) Provide NCCU undergraduate students with an intensive introduction to either basic cancer laboratory research or to the field of public health through a summer educational experience. (2) Assist students in developing the professional skills necessary to gain admission to competitive graduate and professional schools in the biomedical sciences or in public health and to successfully complete those programs. (3) During the academic year following the summer research experience, provide students both discipline-specific training to further develop research skills in their field and interdisciplinary cross-training to build a basic foundation for interdisciplinary research in public health and social, behavioral and biomedical sciences. (4) Facilitate cancer research experiences for UNC-CH students in laboratories and research centers, and in public health-related departments at NCCU.
|House, Alan J; Daye, Laura R; Tarpley, Michael et al. (2015) Design and characterization of a photo-activatable hedgehog probe that mimics the natural lipidated form. Arch Biochem Biophys 567:66-74|
|Kong, Ren; Liu, Timothy; Zhu, Xiaoping et al. (2014) Old drug new use--amoxapine and its metabolites as potent bacterial ?-glucuronidase inhibitors for alleviating cancer drug toxicity. Clin Cancer Res 20:3521-30|
|Chen, Huadong; Fu, Junsheng; Chen, Hao et al. (2014) Ginger compound -shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo. Chem Res Toxicol 27:1575-85|
|Reaves, Denise K; Fagan-Solis, Katerina D; Dunphy, Karen et al. (2014) The role of lipolysis stimulated lipoprotein receptor in breast cancer and directing breast cancer cell behavior. PLoS One 9:e91747|
|Ren, Dongren; Zheng, Gaolin; Bream, Susan et al. (2014) Single nucleotide polymorphisms of caudal type homeobox 1 and 2 are associated with Barrett's esophagus. Dig Dis Sci 59:57-63|
|Singh, Vandana; Raghuwanshi, Sandeep K; Smith, Nikia et al. (2014) G Protein-coupled receptor kinase-6 interacts with activator of G protein signaling-3 to regulate CXCR2-mediated cellular functions. J Immunol 192:2186-94|
|Tarpley, Mike; Abdissa, Temesgen T; Johnson, Gary L et al. (2014) Bosutinib reduces the efficacy of Dasatinib in triple-negative breast cancer cell lines. Anticancer Res 34:1629-35|
|Wordlaw-Stinson, LaShawn; Jones, Sierra; Little, Shaneese et al. (2014) Challenges and Recommendations to Recruiting Women Who Do Not Adhere to Follow-Up Gynecological Care. Open J Prev Med 4:123-128|
|Chen, Hao; Hu, Yuhui; Fang, Yu et al. (2014) Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium. Gut 63:711-9|
|Spruiell, Krisstonia; Richardson, Ricardo M; Cullen, John M et al. (2014) Role of pregnane X receptor in obesity and glucose homeostasis in male mice. J Biol Chem 289:3244-61|
Showing the most recent 10 out of 20 publications