Abstract

? Pilot Projects One pilot project will be funded per year, beginning in Year 2 of the award. The purpose of these projects will be to conduct translational research in Barrett's esophagus that meets the objectives of the BETRNet, falls within one of the four designated Research Areas, and that can utilize effectively the resources available through our integrated Research Center. Cross-BETRNet Activities One Cross-BETRNet project will be funded per year, beginning in Year 2 of the award. The purpose of these projects will be to conduct translational research in Barrett's esophagus that meets the objectives of the BETRNet, falls within one of the four designated Research Areas, and that can feasibly utilize the resources available through our Research Center in combination with the other BETRNet consortia. The below outlined application details will be modified as needed based on guidelines set forth by the BETRNet Steering Committee. In order to minimize duplicated effort, much of the organization, administration, and oversight for Cross-BETRNet Projects is similar to that described above for the Pilot Projects. Additionally, we have commitment from other BETRNet Consortium applicants regarding potential future cross-BETRNet collaborative efforts (see Section 2.7. Letters of Commitment).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163004-04
Application #
8731835
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code

  Publications

Kasagi, Yuta; Chandramouleeswaran, Prasanna M; Whelan, Kelly A et al. (2018) The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial Changes. Cell Mol Gastroenterol Hepatol 5:333-352
May, Michael; Abrams, Julian A (2018) Emerging Insights into the Esophageal Microbiome. Curr Treat Options Gastroenterol 16:72-85
Huo, Xiaofang; Zhang, Xi; Yu, Chunhua et al. (2018) Aspirin prevents NF-?B activation and CDX2 expression stimulated by acid and bile salts in oesophageal squamous cells of patients with Barrett's oesophagus. Gut 67:606-615
Lee, Yoomi; Urbanska, Aleksandra M; Hayakawa, Yoku et al. (2017) Gastrin stimulates a cholecystokinin-2-receptor-expressing cardia progenitor cell and promotes progression of Barrett's-like esophagus. Oncotarget 8:203-214
Schellnegger, Raphael; Quante, Anne; Rospleszcz, Susanne et al. (2017) Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma. Cancer Prev Res (Phila) 10:55-66
Chan, Daniel K; Zakko, Liam; Visrodia, Kavel H et al. (2017) Breath Testing for Barrett's Esophagus Using Exhaled Volatile Organic Compound Profiling With an Electronic Nose Device. Gastroenterology 152:24-26
Ma, M; Shroff, S; Feldman, M et al. (2017) Risk of malignant progression in Barrett's esophagus indefinite for dysplasia. Dis Esophagus 30:1-5
Kraft, Crystal L; Rappaport, Jeffrey A; Snook, Adam E et al. (2017) GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress. Oncotarget 8:102923-102933
Zakko, Liam; Lutzke, Lori; Wang, Kenneth K (2017) Screening and Preventive Strategies in Esophagogastric Cancer. Surg Oncol Clin N Am 26:163-178
Hayakawa, Yoku; Fox, James G; Wang, Timothy C (2017) The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse Models. Cell Mol Gastroenterol Hepatol 3:331-338

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