This proposed Research Center aims to establish a multi-disciplinary, multi-institutional program to develop, optimize, and validate a targeted imaging strategy for the early detection and prevention of cancer in patients with Barrett's esophagus. This research team is formed from world leading investigators from the University of Michigan, University of Washington, and the Mayo Clinic, and has major strengths in clinical and translational research in Barrett's esophagus, genomics, molecular imaging, engineering, bioinfomatics, modeling and pathology. The key members of this team have demonstrated previous collaborations using funding provided by developmental projects in the Network for Translational Research (NTR), a consortium of academic institutions and industrial partners who are working together to develop novel methods for the early detection of colorectal cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163059-03
Application #
8566770
Study Section
Special Emphasis Panel (ZCA1-SRLB-1)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
3
Fiscal Year
2013
Total Cost
$216,646
Indirect Cost
$57,115
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Atreya, Raja; Neumann, Helmut; Neufert, Clemens et al. (2014) In vivo imaging using fluorescent antibodies to tumor necrosis factor predicts therapeutic response in Crohn's disease. Nat Med 20:313-8
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Sturm, Matthew B; Joshi, Bishnu P; Lu, Shaoying et al. (2013) Targeted imaging of esophageal neoplasia with a fluorescently labeled peptide: first-in-human results. Sci Transl Med 5:184ra61
Sturm, Matthew B; Piraka, Cyrus; Elmunzer, B Joseph et al. (2013) In vivo molecular imaging of Barrett's esophagus with confocal laser endomicroscopy. Gastroenterology 145:56-8
Tomizawa, Yutaka; Iyer, Prasad G; Wong Kee Song, Louis M et al. (2013) Safety of endoscopic mucosal resection for Barrett's esophagus. Am J Gastroenterol 108:1440-7; quiz 1448
Khondee, Supang; Wang, Thomas D (2013) Progress in molecular imaging in endoscopy and endomicroscopy for cancer imaging. J Healthc Eng 4:1-22

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