A multi-spectral scanning fiber endoscope (SFE) will be developed to image the panel of fluorescent-labeled peptides developed in Project 2 that have specific binding activity to amplified and/or over expressed gene targets identified in Project 1. Image processing algorithms will be developed to stitch together individual images to form a panorama of the esophageal mucosal surface, and """"""""red-flag"""""""" idenfificafion of highgrade dysplasia and early adenocarcinoma will be performed in Core B to assist the physician by guiding biopsy. The performance of this integrated imaging strategy will be validated in Core C. This instrument will pass through the working channel of a medical endoscope in Phase 1 clinical studies of the individual pepfides assigned to three fiuorescent-labels in Project 2. The expected establishment of safety will prepare this system for a future multi-center clinical validation study.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Ann Arbor
United States
Zip Code
Joshi, Bishnu P; Duan, Xiyu; Kwon, Richard S et al. (2016) Multimodal endoscope can quantify wide-field fluorescence detection of Barrett's neoplasia. Endoscopy 48:A1-A13
Joshi, Bishnu P; Wang, Thomas D (2016) Gastrointestinal imaging in 2015: Emerging trends in endoscopic imaging. Nat Rev Gastroenterol Hepatol 13:72-3
Joshi, Bishnu P; Zhou, Juan; Pant, Asha et al. (2016) Design and Synthesis of Near-Infrared Peptide for in Vivo Molecular Imaging of HER2. Bioconjug Chem 27:481-94
Zhou, Quan; Li, Zhao; Zhou, Juan et al. (2016) In vivo photoacoustic tomography of EGFR overexpressed in hepatocellular carcinoma mouse xenograft. Photoacoustics 4:43-54
Zhou, Juan; Joshi, Bishnu P; Duan, Xiyu et al. (2015) EGFR Overexpressed in Colonic Neoplasia Can be Detected on Wide-Field Endoscopic Imaging. Clin Transl Gastroenterol 6:e101
Myers, Amy L; Lin, Lin; Nancarrow, Derek J et al. (2015) IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma. Oncotarget 6:25897-916
Stachler, Matthew D; Taylor-Weiner, Amaro; Peng, Shouyong et al. (2015) Paired exome analysis of Barrett's esophagus and adenocarcinoma. Nat Genet 47:1047-55
Sturm, Matthew B; Wang, Thomas D (2015) Emerging optical methods for surveillance of Barrett's oesophagus. Gut 64:1816-23
Lin, Jules; Myers, Amy L; Wang, Zhuwen et al. (2015) Osteopontin (OPN/SPP1) isoforms collectively enhance tumor cell invasion and dissemination in esophageal adenocarcinoma. Oncotarget 6:22239-57
Jiang, Hui; Salzman, Julia (2015) A penalized likelihood approach for robust estimation of isoform expression. Stat Interface 8:437-445

Showing the most recent 10 out of 36 publications