Little is known about Barretts esophagus (BE) in terms of its etiology, although it is most likely caused by the complex interplay between genes and environmental factors and it is known to be a direct precursor to Esophageal cancer (EAC). Therefore, large-scale research projects, such as the ones proposed in this BETRNet Translational Research Center (TRC) application, are necessary to have an impact on early detection, diagnosis and prevention. We will develop a centralized Bioinformatics Core infrastructure to support data management, study design, and statistical/bioinformatic analysis for all proposed projects and to help facilitate data sharing and the capacity to link and share data and biospecimens with the BETRNet Data Coordination Center. This Core will meet the requirements for both this application as a whole, for each individual project within this application and for cross-pollination between this TRC and the other funded TRCs under this RFA, leading to many scientific manuscripts and submission of additional grants and pilot projects. Matching the theme and structure of the components of this multi-institutional TRC proposal, this Bioinformatics Core is drawn from faculty at the Case Comprehensive Cancer Center, the Department of Epidemiology and Biostatistics and the Department of Genetics at the Case Western Reserve University (CWRU) School of Medicine, the Department of Public Health Sciences at the Fred Hutchinson Cancer Research Center at the University of Washington and the Department of Biostatistics at the University of North Carolina School of Medicine.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163060-02
Application #
8555515
Study Section
Special Emphasis Panel (ZCA1-SRLB-1 (O1))
Project Start
2011-09-26
Project End
2016-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
2
Fiscal Year
2012
Total Cost
$144,772
Indirect Cost
$37,845
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
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Curtius, Kit; Wong, Chao-Jen; Hazelton, William D et al. (2016) A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus. PLoS Comput Biol 12:e1004919
Kendall, Bradley J; Rubenstein, Joel H; Cook, Michael B et al. (2016) Inverse Association Between Gluteofemoral Obesity and Risk of Barrett's Esophagus in a Pooled Analysis. Clin Gastroenterol Hepatol 14:1412-1419.e3
Fecteau, Ryan E; Kong, Jianping; Kresak, Adam et al. (2016) Association Between Germline Mutation in VSIG10L and Familial Barrett Neoplasia. JAMA Oncol 2:1333-1339
Blum, Andrew E; Venkitachalam, Srividya; Guo, Yan et al. (2016) RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas. Cancer Res 76:5628-5633
Venkitachalam, Srividya; Revoredo, Leslie; Varadan, Vinay et al. (2016) Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer. Sci Rep 6:23642

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