The overall objective of the Translational Research Center - F Developmental Research Program (TRCFDRP) is to develop innovative and diverse approaches to focus on Barrett's esophagus and esophageal adenocarcinoma translational research across the spectrum from etiology through prevention screening, diagnostics, and therapeutics. The TRCFDRP will provide 1) financial support, 2) Bioinformatic support 3) TRC-F resources and 4) intellectual oversight and advice for pilot research projects and investigators. Funds for development of pilot research projects are critical to ongoing development and enhancement of the TRC-F and the TRC-F will allocate $150,000 per year for years 2-5 for pilot projects to be used $50,000 per year for pilot projects from within the TRC-F and $100,000 per year for cross center projects. Within-center and Cross Center Pilot Projects will be solicited, reviewed and awarded by the BETRNet Steering Committee on a merit basis with evaluation criteria based on scientific merit, impact, significance, innovation, transdisciplinary characteristics, translational potential, with great significance attached to the potential for the contribution to enhance and extend BETRNet projects as well as the potential for developing into independent research projects. In addition, cross-center pilot projects will consider potential contribution of applications to increase sample size, provide complimentary skills, resources and/or expertise or collaborations with other Translational Research Centers or other multi-institutional cooperative groups. Emphasis will be placed on supporting new investigators as well as established investigators with new approaches. For meritorious proposals from individual basic or clinical investigators, the TRCFDRP leadership group will identify complementary translational investigators to serve as advisors. An innovative approach that we will initiate to engage expertise from both inside and outside the TRC-F will be to post on the Cancer Center website and the national BETRNet website, a series of Research Opportunities in which each TRC-F project will provide a list of research questions, resources, expertise, etc. that will be available for collaborative pilot project research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163060-04
Application #
8721890
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Venkitachalam, Srividya; Guda, Kishore (2017) Altered glycosyltransferases in colorectal cancer. Expert Rev Gastroenterol Hepatol 11:5-7
Morris, Shelli M; Davison, Jerry; Carter, Kelly T et al. (2017) Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms. Int J Cancer 140:853-863
Cummings, Linda C; Thota, Prashanthi N; Willis, Joseph E et al. (2017) A nonrandomized trial of vitamin D supplementation for Barrett's esophagus. PLoS One 12:e0184928
Luebeck, E Georg; Curtius, Kit; Hazelton, William D et al. (2017) Identification of a key role of widespread epigenetic drift in Barrett's esophagus and esophageal adenocarcinoma. Clin Epigenetics 9:113
Krishnamoorthi, Rajesh; Borah, Bijan; Heien, Herbert et al. (2016) Rates and predictors of progression to esophageal carcinoma in a large population-based Barrett's esophagus cohort. Gastrointest Endosc 84:40-46.e7
Curtius, Kit; Wong, Chao-Jen; Hazelton, William D et al. (2016) A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus. PLoS Comput Biol 12:e1004919
Kendall, Bradley J; Rubenstein, Joel H; Cook, Michael B et al. (2016) Inverse Association Between Gluteofemoral Obesity and Risk of Barrett's Esophagus in a Pooled Analysis. Clin Gastroenterol Hepatol 14:1412-1419.e3
Fecteau, Ryan E; Kong, Jianping; Kresak, Adam et al. (2016) Association Between Germline Mutation in VSIG10L and Familial Barrett Neoplasia. JAMA Oncol 2:1333-1339
Blum, Andrew E; Venkitachalam, Srividya; Guo, Yan et al. (2016) RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas. Cancer Res 76:5628-5633
Venkitachalam, Srividya; Revoredo, Leslie; Varadan, Vinay et al. (2016) Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer. Sci Rep 6:23642

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