Breast cancer, the most commonly diagnosed cancer among women in the United States, is the second leading cause of cancer death (Ries et al., 2010). Current breast cancer incidence rates in the United States are higher among Caucasians than among African Americans. However, breast cancer mortality rates are higher among African Americans than among Caucasians, perhaps due to the tendency of African American women to be diagnosed with more aggressive disease than Caucasian women (Ries et al., 2010). Some of the environmental risk factors for breast cancer identified among Caucasian women (e.g., early age at menarche, late age at menopause, lack of physical activity) appear to operate differently in African American women (Bernstein et al., 2003). Few genetic studies of breast cancer have included a sufficient number of African American women to determine whether genetic risk factors or the interaction of genetic and environmental risk factors for breast cancer operate similarly in Caucasian and African American women (Jones et al., 2004). Little is understood about the etiology of breast cancer nor do we know what genetic and environmental factors might help explain racial disparities in breast cancer incidence and mortality.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163066-04
Application #
8725086
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Tennessee State University
Department
Type
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37209
Vercruysse, Koen; Clark, Astiney; Alatas, Noor et al. (2018) Polysaccharide-mediated synthesis of melanins from serotonin and other 5-hydroxy indoles. Future Sci OA 4:FSO280
Husaini, Baqar A; Taira, Deborah; Norris, Keith et al. (2018) Depression Effects on Hospital Cost of Heart Failure Patients in California: An Analysis by Ethnicity and Gender. Indian J Community Med 43:49-52
Lawrence, Shanieek; Ismail, Farah; Jamal, Sarah Z et al. (2018) Tributyltin stimulates synthesis of interferon gamma and tumor necrosis factor alpha in human lymphocytes. J Appl Toxicol 38:1081-1090
Alotaibi, Dalal; Amara, Suneetha; Johnson, Terrance L et al. (2018) Potential anticancer effect of prostratin through SIK3 inhibition. Oncol Lett 15:3252-3258
Brown, Shyretha; Boules, Mariam; Hamza, Nafisa et al. (2018) Synthesis of interleukin 1 beta and interleukin 6 in human lymphocytes is stimulated by tributyltin. Arch Toxicol 92:2573-2586
Odoh, C; Sanderson, M; Williams, E A et al. (2018) Operationalizing outcome measures of human papillomavirus vaccination among adolescents. Public Health 159:129-132
Yasmin, Sharia; Whalen, Margaret (2018) Flame retardants, hexabromocyclododecane (HCBD) and tetrabromobisphenol a (TBBPA), alter secretion of tumor necrosis factor alpha (TNF?) from human immune cells. Arch Toxicol 92:1483-1494
Brown, Shyretha; Wilburn, Wendy; Martin, Tyesha et al. (2018) Butyltin compounds alter secretion of interleukin 6 from human immune cells. J Appl Toxicol 38:201-218
Massawe, Reda; Drabo, Leon; Whalen, Margaret (2017) Effects of pentachlorophenol and dichlorodiphenyltrichloroethane on secretion of interferon gamma (IFN?) and tumor necrosis factor alpha (TNF?) from human immune cells. Toxicol Mech Methods 27:223-235
Amara, Suneetha; Majors, Ciera; Roy, Bipradas et al. (2017) Critical role of SIK3 in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation. PLoS One 12:e0180097

Showing the most recent 10 out of 76 publications