Breast cancer, the most commonly diagnosed cancer among women in the United States, is the second leading cause of cancer death (Ries et al., 2010). Current breast cancer incidence rates in the United States are higher among Caucasians than among African Americans. However, breast cancer mortality rates are higher among African Americans than among Caucasians, perhaps due to the tendency of African American women to be diagnosed with more aggressive disease than Caucasian women (Ries et al., 2010). Some of the environmental risk factors for breast cancer identified among Caucasian women (e.g., early age at menarche, late age at menopause, lack of physical activity) appear to operate differently in African American women (Bernstein et al., 2003). Few genetic studies of breast cancer have included a sufficient number of African American women to determine whether genetic risk factors or the interaction of genetic and environmental risk factors for breast cancer operate similarly in Caucasian and African American women (Jones et al., 2004). Little is understood about the etiology of breast cancer nor do we know what genetic and environmental factors might help explain racial disparities in breast cancer incidence and mortality.

Agency
National Institute of Health (NIH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163066-04
Application #
8725086
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Tennessee State University
Department
Type
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37209
Selove, Rebecca; Foster, Maya; Mack, Raquel et al. (2016) Using an Implementation Research Framework to Identify Potential Facilitators and Barriers of an Intervention to Increase HPV Vaccine Uptake. J Public Health Manag Pract :
Martin, Tamara J; Whalen, Margaret M (2016) Exposures to the environmental toxicants pentachlorophenol (PCP) and dichlorodiphenyltrichloroethane (DDT) modify secretion of interleukin 1-beta (IL-1β) from human immune cells. Arch Toxicol :
Almughamsi, Haifa; Whalen, Margaret M (2016) Hexabromocyclododecane and tetrabromobisphenol A alter secretion of interferon gamma (IFN-γ) from human immune cells. Arch Toxicol 90:1695-707
Yoon, Byung-Hak; Lee, Jae Hyup; Na, Kyuheum et al. (2016) The effects of a single intravenous injection of novel activin A/BMP-2 (AB204) on toxicity and the respiratory and central nervous systems. Drug Chem Toxicol 39:284-9
Anisuzzaman, Sharif; Whalen, Margaret M (2016) Tetrabromobisphenol A and hexabromocyclododecane alter secretion of IL-1β from human immune cells. J Immunotoxicol 13:403-16
Amara, Suneetha; Zheng, Mu; Tiriveedhi, Venkataswarup (2016) Oleanolic Acid Inhibits High Salt-Induced Exaggeration of Warburg-like Metabolism in Breast Cancer Cells. Cell Biochem Biophys 74:427-34
Amara, Suneetha; Ivy, Michael T; Myles, Elbert L et al. (2016) Sodium channel γENaC mediates IL-17 synergized high salt induced inflammatory stress in breast cancer cells. Cell Immunol 302:1-10
Selove, Rebecca; Kilbourne, Barbara; Fadden, Mary Kay et al. (2016) Time from Screening Mammography to Biopsy and from Biopsy to Breast Cancer Treatment among Black and White, Women Medicare Beneficiaries Not Participating in a Health Maintenance Organization. Womens Health Issues 26:642-647
Amara, Suneetha; Alotaibi, Dalal; Tiriveedhi, Venkataswarup (2016) NFAT5/STAT3 interaction mediates synergism of high salt with IL-17 towards induction of VEGF-A expression in breast cancer cells. Oncol Lett 12:933-943
Lawrence, Shanieek; Pellom Jr, Samuel T; Shanker, Anil et al. (2016) Tributyltin exposure alters cytokine levels in mouse serum. J Immunotoxicol 13:870-878

Showing the most recent 10 out of 59 publications