Abstract

In this application, we propose to intensify the role of our existing MVTCP shared resource cores: Clinical Trials Core (CTC), Bioinfomatics and Biostatistics Core (BBC), and Translational Pathology Core (TPC). These cores have been instrumental in the success of our Cancer Partnership in the previous funding cycles and will continue to facilitate and accelerate the success of full research projects (3), pilot project (1), as well as the Education and Cancer Outreach cores. In this renewal application, specific aims for the Cores are to: 1. Promote and support access of minority and underserved patients onto clinical trials that are usually not available at community public hospitals (Clinical Trials Core); 2. Provide professional expertise in biostatistics and bioinformatics for all cancer-related research in the MVTCP (Bioinfomatics and Biostatistics Core); and 3. Facilitate studies of MVTCP investigators that involve tissue analysis by collecting and banking human tissues from majority and minority populations and providing state of the art technology for analysis of these tissues along with instruction to students and faculty on the latest technologies available (Translational Pathology Core).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163072-09
Application #
9550794
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
9
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
079917897
City
Nashville
State
TN
Country
United States
Zip Code
37232

  Publications

Hull, P C; Buchowski, M; Canedo, J R et al. (2018) Childhood obesity prevention cluster randomized trial for Hispanic families: outcomes of the healthy families study. Pediatr Obes 13:686-696
Santos-Barriopedro, Irene; Bosch-Presegué, Laia; Marazuela-Duque, Anna et al. (2018) SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-?B pathway. Nat Commun 9:101
Alotaibi, Dalal; Amara, Suneetha; Johnson, Terrance L et al. (2018) Potential anticancer effect of prostratin through SIK3 inhibition. Oncol Lett 15:3252-3258
Odoh, C; Sanderson, M; Williams, E A et al. (2018) Operationalizing outcome measures of human papillomavirus vaccination among adolescents. Public Health 159:129-132
Yang, Yaohua; Cai, Qiuyin; Shu, Xiao-Ou et al. (2018) Prospective study of oral microbiome and colorectal cancer risk in low-income and African American populations. Int J Cancer :
Hull, Pamela; Emerson, Janice S; Quirk, Meghan E et al. (2017) A Smartphone App for Families With Preschool-Aged Children in a Public Nutrition Program: Prototype Development and Beta-Testing. JMIR Mhealth Uhealth 5:e102
Ho, Meng-Hsuan; Lamont, Richard J; Xie, Hua (2017) Identification of Streptococcus cristatus peptides that repress expression of virulence genes in Porphyromonas gingivalis. Sci Rep 7:1413
Uzhachenko, Roman; Boyd, Kelli; Olivares-Villagomez, Danyvid et al. (2017) Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis. Aging (Albany NY) 9:627-649
Brown, Shyretha; Tehrani, Shahin; Whalen, Margaret M (2017) Dibutyltin-induced alterations of interleukin 1beta secretion from human immune cells. J Appl Toxicol 37:181-191
Amara, Suneetha; Tiriveedhi, Venkataswarup (2017) The Five Immune Forces Impacting DNA-Based Cancer Immunotherapeutic Strategy. Int J Mol Sci 18:

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