The fact that (i) 80% of hepatocellular carcinomas (HCCs) arise in fibrotic livers and that (ii) chronic injury, inflammation and fibrosis are sufficient to induce HCC suggest that HCC truly represents

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163111-02
Application #
8555377
Study Section
Special Emphasis Panel (ZCA1-SRLB-3 (O1))
Project Start
2011-09-22
Project End
2016-07-31
Budget Start
2012-09-01
Budget End
2013-07-31
Support Year
2
Fiscal Year
2012
Total Cost
$180,345
Indirect Cost
$56,069
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Caviglia, Jorge Matias; Yan, Jun; Jang, Myoung-Kuk et al. (2017) MicroRNA-21 and Dicer are dispensable for hepatic stellate cell activation and the development of liver fibrosis. Hepatology :
Pradère, Jean-Philippe; Hernandez, Céline; Koppe, Christiane et al. (2016) Negative regulation of NF-?B p65 activity by serine 536 phosphorylation. Sci Signal 9:ra85
Boggs, Kristin; Venkatesan, Nandakumar; Mederacke, Ingmar et al. (2016) Contribution of Underlying Connective Tissue Cells to Taste Buds in Mouse Tongue and Soft Palate. PLoS One 11:e0146475
Mu, Xueru; Pradere, Jean-Philippe; Affò, Silvia et al. (2016) Epithelial Transforming Growth Factor-? Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma. Gastroenterology 150:720-33
Manuel, Edwin R; Chen, Jeremy; D'Apuzzo, Massimo et al. (2015) Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors. Cancer Immunol Res 3:1096-107
Mu, Xueru; Español-Suñer, Regina; Mederacke, Ingmar et al. (2015) Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment. J Clin Invest 125:3891-903
Duann, Pu; Li, Haichang; Lin, Peihui et al. (2015) MG53-mediated cell membrane repair protects against acute kidney injury. Sci Transl Med 7:279ra36
Caviglia, Jorge Matias; Schwabe, Robert F (2015) Mouse models of liver cancer. Methods Mol Biol 1267:165-83
Luedde, Tom; Kaplowitz, Neil; Schwabe, Robert F (2014) Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology 147:765-783.e4
Huebener, Peter; Gwak, Geum-Youn; Pradere, Jean-Philippe et al. (2014) High-mobility group box 1 is dispensable for autophagy, mitochondrial quality control, and organ function in vivo. Cell Metab 19:539-47

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