The aim of the TMEN Human Sample Acquisition Core (HSAC) is the collection of human biological material with associated clinical information to facilitate translational research of the individual projects. This core will build on the already existing resources of the University of Michigan Prostate SPORE to make the best use of available resources. Quality assurance is maintained through the staff of the Prostate SPORE pathologists. Clinical consent and patient participation is conducted by Dr. Pienta through the Prostate Cancer Clinic at the University of Michigan. The informatics infrastructure of the Human Sample Acquisition Core is provided by an instance of caTissue as hosted by the Prostate SPORE and is coordinated by the Directors of the Division of Pathology Informatics. Specifically, the aim of the HSAC is to (i) collect blood for circulating tumor cells, white blood cells, and serum, (Ii) to collect bone marrow from aspirates and biopsies for mesenchymal cells, disseminated tumor cells and serum, and (iii) collect metastatic tissue from the University of Michigan Rapid Autopsy Program (RAP). Support for tissue banking and collection of tissue from the RAP is provided by the SPORE. Support is only being requested to collect and process blood and bone marrow.
This TMEN will be focused on the mechanisms that regulate dormancy of skeletal metastases in prostate cancer. This core will oversee the operations of the entire Program to ensure that it moves forward in a direction that addresses this important clinical problem.
|Jung, Younghun; Wang, Jingcheng; Lee, Eunsohl et al. (2015) Annexin 2-CXCL12 interactions regulate metastatic cell targeting and growth in the bone marrow. Mol Cancer Res 13:197-207|
|Cordeiro-Spinetti, Eric; Taichman, Russell S; Balduino, Alex (2015) The bone marrow endosteal niche: how far from the surface? J Cell Biochem 116:11-Jun|
|Roca, Hernan; Pande, Manjusha; Huo, Jeffrey S et al. (2014) A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial - mesenchymal cell reprogramming and cancer progression. BMC Syst Biol 8:29|
|Axelrod, Haley; Pienta, Kenneth J (2014) Axl as a mediator of cellular growth and survival. Oncotarget 5:8818-52|
|Yumoto, Kenji; Berry, Janice E; Taichman, Russell S et al. (2014) A novel method for monitoring tumor proliferation in vivo using fluorescent dye DiD. Cytometry A 85:548-55|
|Yumoto, Kenji; Eber, Matthew R; Berry, Janice E et al. (2014) Molecular pathways: niches in metastatic dormancy. Clin Cancer Res 20:3384-9|
|Yang, Kimberline R; Mooney, Steven M; Zarif, Jelani C et al. (2014) Niche inheritance: a cooperative pathway to enhance cancer cell fitness through ecosystem engineering. J Cell Biochem 115:1478-85|
|Wan, Liling; Hu, Guohong; Wei, Yong et al. (2014) Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res 74:5336-47|
|Shiozawa, Yusuke; McGee, Samantha; Pienta, Michael J et al. (2013) Erythropoietin supports the survival of prostate cancer, but not growth and bone metastasis. J Cell Biochem 114:2471-8|
|Taichman, Russell S; Patel, Lalit R; Bedenis, Rachel et al. (2013) GAS6 receptor status is associated with dormancy and bone metastatic tumor formation. PLoS One 8:e61873|
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