The Administrative Core will have eight central goals: (a) facilitating interaction and communication along the participating research groups;(b) forming a repository of information for research resources generated by program investigators available to other project investigators;(c) obtaining constructive criticism from extramural and intramural scientists that may help investigators to obtain their research goals;(d) coordinating Resource sharing to the broad scientific community (i.e. Resource Sharing);(e) providing biostatistical support to all of the projects;(f) performing the reporting tasks required by the NIH;(g) ensuring appropriate approvals (i.e. radiation, human subjects, animal welfare, DNA) are obtained and adhered to;and (h) providing administrative services to the project as a whole. The Core will be directed by Dr. Russell S. Taichman. Support is requested for an individual who will manage the fiscal administration and general program activities. Ms. Stephanie Daignault will provide biostatistical support. These goals will be accomplished by a variety of activities including: Weekly Project Leader meetings Monthly Project Team meetings Annual one-day visits by our External Advisory Board Annual one-day visits with our Internal Advisory Board Biostatistical review of all animal projects prior to initiation of the project.

Public Health Relevance

This TMEN is focused on the mechanisms that regulate dormancy of skeletal metastases in prostate cancer. This core will oversee the operations of the entire Program to ensure that it moves forward in a direction that addresses this important clinical problem.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-3)
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University of Michigan Ann Arbor
Ann Arbor
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Jung, Younghun; Wang, Jingcheng; Lee, Eunsohl et al. (2015) Annexin 2-CXCL12 interactions regulate metastatic cell targeting and growth in the bone marrow. Mol Cancer Res 13:197-207
Cordeiro-Spinetti, Eric; Taichman, Russell S; Balduino, Alex (2015) The bone marrow endosteal niche: how far from the surface? J Cell Biochem 116:11-Jun
Roca, Hernan; Pande, Manjusha; Huo, Jeffrey S et al. (2014) A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial - mesenchymal cell reprogramming and cancer progression. BMC Syst Biol 8:29
Axelrod, Haley; Pienta, Kenneth J (2014) Axl as a mediator of cellular growth and survival. Oncotarget 5:8818-52
Yumoto, Kenji; Berry, Janice E; Taichman, Russell S et al. (2014) A novel method for monitoring tumor proliferation in vivo using fluorescent dye DiD. Cytometry A 85:548-55
Yumoto, Kenji; Eber, Matthew R; Berry, Janice E et al. (2014) Molecular pathways: niches in metastatic dormancy. Clin Cancer Res 20:3384-9
Yang, Kimberline R; Mooney, Steven M; Zarif, Jelani C et al. (2014) Niche inheritance: a cooperative pathway to enhance cancer cell fitness through ecosystem engineering. J Cell Biochem 115:1478-85
Wan, Liling; Hu, Guohong; Wei, Yong et al. (2014) Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res 74:5336-47
Shiozawa, Yusuke; McGee, Samantha; Pienta, Michael J et al. (2013) Erythropoietin supports the survival of prostate cancer, but not growth and bone metastasis. J Cell Biochem 114:2471-8
Taichman, Russell S; Patel, Lalit R; Bedenis, Rachel et al. (2013) GAS6 receptor status is associated with dormancy and bone metastatic tumor formation. PLoS One 8:e61873

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