Metastasis is a multi-step process that involves multiple different tissue components supporting a heterotopic cancer cell. We propose that mesenchymal cell interactions with cancer cells play a critical role in the successful engraftment of the cancer in a metastatic site. We will test that hypothesis through the examination and manipulafion of specific subsets of mesenchymal cells interacting with primary prostate cancer cells of defined genotype. PHS

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163191-05
Application #
8933402
Study Section
Special Emphasis Panel (ZCA1-SRLB-3 (O1))
Program Officer
Mohla, Suresh
Project Start
2011-09-26
Project End
2016-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
5
Fiscal Year
2014
Total Cost
$449,984
Indirect Cost
$137,061
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
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