The program director of the Center will be Raghu Kalluri, who will have the primary responsibility for overseeing all research activities, administrative and financial acfivities of the projects within the center, and also facilitate interactions with the TMEN steering committee and other TMEN networks. Pier Paolo Pandolfi and David Scadden will assist in these activifies and make themselves available to TMEN steering committee meefings and in fostering interacfions with other TMEN participants. Raghu Kalluri has experience with the management and administration of multi-investigator translafional studies. He is currently the Chief of division and in-charge of 42 clinicians and researchers. He will seek confinual input, advice, and approval from the Center internal advisory Committee comprised of co-leaders and investigators of each major project and other members ofthe BIDMC Harvard Medical School'community. He will seek the advice and the guidance of the External Advisory Committee as needed and also during organized annual meefings with the committee.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-SRLB-3 (O1))
Program Officer
Mohla, Suresh
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas MD Anderson Cancer Center
United States
Zip Code
Melo, Sonia A; Sugimoto, Hikaru; O'Connell, Joyce T et al. (2014) Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell 26:707-21
Wang, Ying-Hua; Israelsen, William J; Lee, Dongjun et al. (2014) Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell 158:1309-23
Scadden, David T (2014) Nice neighborhood: emerging concepts of the stem cell niche. Cell 157:41-50
Charytan, David M; Padera, Robert; Helfand, Alexander M et al. (2014) Increased concentration of circulating angiogenesis and nitric oxide inhibitors induces endothelial to mesenchymal transition and myocardial fibrosis in patients with chronic kidney disease. Int J Cardiol 176:99-109
Özdemir, Berna C; Pentcheva-Hoang, Tsvetelina; Carstens, Julienne L et al. (2014) Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 25:719-34
Zeisberg, Michael; Tampe, Björn; LeBleu, Valerie et al. (2014) Thrombospondin-1 deficiency causes a shift from fibroproliferative to inflammatory kidney disease and delays onset of renal failure. Am J Pathol 184:2687-98
LeBleu, Valerie S; Taduri, Gangadhar; O'Connell, Joyce et al. (2013) Origin and function of myofibroblasts in kidney fibrosis. Nat Med 19:1047-53
Krause, Daniela S; Fulzele, Keertik; Catic, Andre et al. (2013) Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nat Med 19:1513-7
LeBleu, Valerie S; Teng, Yingqi; O'Connell, Joyce T et al. (2013) Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis. Nat Med 19:227-31
Zeisberg, Michael; Kalluri, Raghu (2013) Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis. Am J Physiol Cell Physiol 304:C216-25

Showing the most recent 10 out of 12 publications