The overarching goal of our proposed project, SuCCESS: Studying Colorectal Cancer: Effectiveness of Screening Strategies, is to develop evidence to inform personalized screening recommendations that maintain most or all of the benefits of intensive screening, minimize risks and costs, and respect patient preferences. Based within Group Health Research Institute (GHRI), the SuCCESS project will draw on a wide array of rich electronic data sources available at Group Health (GH), an integrated health care delivery system in Washington State, to gather information about risk factors, screening patterns, diagnostic procedures, pathology, treatment, and cancer outcomes among GH enrollees. The SuCCESS project will use GH data to describe colorectal cancer (CRC) screening as practiced, including behaviors and effectiveness, and will build on this information to examine the potential for personalized screening regimens. We propose 3 linked projects related to this overall goal. Project 1, """"""""Comparative effectiveness of colorectal cancer screening as practiced,"""""""" will provide information about how screening is practiced, about patient decisions regarding screening modalities, and about the comparative effectiveness of different screening regimens as practiced. Project 2: """"""""Personalizing colorectal cancer screening and surveillance,"""""""" will focus on identifying effective personalized screening regimens based on screening history and other individual risk factors. Project 3, """"""""Modeling long-term comparative effectiveness of colorectal screening,"""""""" will use disease simulation models to predict the long-term effectiveness of different screening and surveillance regimens on botii overall and CRC mortality based on results from Project 1 and Project 2, and will develop a cohort model for CRC that will be freely distributed. Our proposed body of research will provide an important foundation for personalized clorectal cancer screening, and will produce results that are useful to a multidisciplinary audience, including clinicians, patients, policy makers, researchers, and professional medical organizations.

Public Health Relevance

Our proposed research will provide new information to guide patient and provider decisions about selection of screening tests. For individuals already in screening, our research will provide information about screening and surveillance intensity, including the possibility of screening cessation.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163261-02
Application #
8335410
Study Section
Special Emphasis Panel (ZCA1-SRLB-R (O1))
Program Officer
Ambs, Anita
Project Start
2011-09-20
Project End
2016-05-31
Budget Start
2012-09-01
Budget End
2013-05-31
Support Year
2
Fiscal Year
2012
Total Cost
$846,335
Indirect Cost
$437,277
Name
Group Health Cooperative
Department
Type
DUNS #
078198520
City
Seattle
State
WA
Country
United States
Zip Code
98101
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Tosteson, Anna N A; Beaber, Elisabeth F; Tiro, Jasmin et al. (2016) Variation in Screening Abnormality Rates and Follow-Up of Breast, Cervical and Colorectal Cancer Screening within the PROSPR Consortium. J Gen Intern Med 31:372-9
Chubak, Jessica; Hubbard, Rebecca (2016) Defining and measuring adherence to cancer screening. J Med Screen 23:179-185
Corley, Douglas A; Haas, Jennifer S; Kobrin, Sarah (2016) Reducing Variation in the ""Standard of Care"" for Cancer Screening: Recommendations From the PROSPR Consortium. JAMA 315:2067-8
Chubak, Jessica; Hubbard, Rebecca A; Johnson, Eric et al. (2015) Assessing the effectiveness of a cancer screening test in the presence of another screening modality. J Med Screen 22:69-75
Rutter, Carolyn M; Greenlee, Robert T; Johnson, Eric et al. (2015) Prevalence of colonoscopy before age 50. Prev Med 72:126-9

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