Public Health Relevance

Breast cancer screening detects many early stage breast cancers (ductal carcinoma in situ or ''DCIS'') that are unlikely to threaten a woman's life. However; aggressive treatment is recommended for all women with DCIS because we cannot currently identify which of these DCIS cases are potentially life threatening. Our research is focused on finding ways to know which DCIS cases are unlikely to progress to invasive cancer so that these women do not have to suffer needlessly from the side effects of aggressive treatment.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-R (O1))
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University of Vermont & St Agric College
United States
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Onega, Tracy; Weaver, Donald L; Frederick, Paul D et al. (2017) The diagnostic challenge of low-grade ductal carcinoma in situ. Eur J Cancer 80:39-47
Engmann, Natalie J; Golmakani, Marzieh K; Miglioretti, Diana L et al. (2017) Population-Attributable Risk Proportion of Clinical Risk Factors for Breast Cancer. JAMA Oncol 3:1228-1236
Samples, Laura S; Rendi, Mara H; Frederick, Paul D et al. (2017) Surgical implications and variability in the use of the flat epithelial atypia diagnosis on breast biopsy specimens. Breast 34:34-43
Onega, Tracy; Weiss, Julie E; Goodrich, Martha E et al. (2017) Relationship between preoperative breast MRI and surgical treatment of non-metastatic breast cancer. J Surg Oncol 116:1008-1015
Knerr, Sarah; Wernli, Karen J; Leppig, Kathleen et al. (2017) A web-based personalized risk communication and decision-making tool for women with dense breasts: Design and methods of a randomized controlled trial within an integrated health care system. Contemp Clin Trials 56:25-33
Haas, Jennifer S; Barlow, William E; Schapira, Marilyn M et al. (2017) Primary Care Providers' Beliefs and Recommendations and Use of Screening Mammography by their Patients. J Gen Intern Med 32:449-457
Jackson, Sara L; Frederick, Paul D; Pepe, Margaret S et al. (2017) Diagnostic Reproducibility: What Happens When the Same Pathologist Interprets the Same Breast Biopsy Specimen at Two Points in Time? Ann Surg Oncol 24:1234-1241
Shiyanbola, Oyewale O; Arao, Robert F; Miglioretti, Diana L et al. (2017) Emerging Trends in Family History of Breast Cancer and Associated Risk. Cancer Epidemiol Biomarkers Prev 26:1753-1760
Lehman, Constance D; Arao, Robert F; Sprague, Brian L et al. (2017) National Performance Benchmarks for Modern Screening Digital Mammography: Update from the Breast Cancer Surveillance Consortium. Radiology 283:49-58
Leopold, Robin B; Thomas, Alexander W; Concannon, Kyle F et al. (2017) Breast cancer screening in patients with cancers other than breast. Breast Cancer Res Treat 163:343-348

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