Project 1 Our novel proposal will study a longitudinal cohort of Kenyan women, balanced for human immunodeficiency virus (HIV) infection (approximately 50% HIV-infected and 50% non-HIV-infected), and is designed to capture new information about the largely unstudied time period between oncogenic human papillomavirus (HPV) infection in early adulthood and cervical cancer in later adult years. There is a need to study the sociocultural factors that affect HPV infections and the incidence and severity of HPV-related disease in HIV-infected women. The core objective of this application is to better understand the natural history of oncogenic HPV infections in HIV-infected Kenyan women, and the potentially modifiable (and non-modifiable) factors that are associated with progression of oncogenic HPV infection to clinical disease, including cervical cancer.

Public Health Relevance

Why do Kenyan women suffer from such a high risk of cervical cancer? Is it entry related to HIV-coinfection? This project is designed to answer these and other questions related to cervical cancer in HIV-infected Kenyan women.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54CA190151-01
Application #
8935184
Study Section
Special Emphasis Panel (ZCA1-RPRB-O (M2))
Program Officer
Dominguez, Geraldina
Project Start
2014-09-19
Project End
2019-08-31
Budget Start
2014-09-19
Budget End
2015-08-31
Support Year
1
Fiscal Year
2014
Total Cost
$150,068
Indirect Cost
$27,555
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202