The overall goal of The Medication Development Center for Cocaine Use Disorder is to employ translational drug interaction, self-administration, and cue reactivity studies as tools to advance medication development in cocaine use disorder. The Administrative Core will promote this goal by serving as a general resource for the three projects and the Educational Core.
The specific aims of the Administrative core are:
Aim 1. To provide infrastructure support for data storage, analysis, evaluation, and propagation of study results within and between the three Projects through: a) providing database support for the three projects, b) bringing together the necessary internal and external expertise to evaluate and integrate the translational information provided by the three projects, including NIDA program staff and representatives from the pharmaceutical industry, and c) providing support for presentation of findings at scientific meetings and publication of results in peer review journals.
Aim 2. To provide funding and infrastructure for pilot projects targeted at junior faculty and trainees.
Aim 3. To provide infrastructure support for clinical research including: a) subject recruitment and screening, b) urine toxicology testing, c) ensuring subject confidentiality and compliance IRB and HIPAA requirements and regulations, d) documenting clinical trials on clinicaltrials.gov, and e) oversight of data sharing with NIDA and documentation of any serious adverse events in the NIDA Serious Adverse Events Tracking System (SAETRS).
Aim 4. To provide Fiscal and Management support including budgetary oversight, and management of research staff.
Aim 5. To serve as the Liaison between the Center and outside entities including NIDA program staff, the external advisory board, the Centers for Clinical and Translational Science at VCU and UTMB, pharmaceutical Industry, and collaborating entities including addiction researchers at outside institutions.

Public Health Relevance

Cocaine use disorder (CocUD) continues to be a significant health problem in the US, with 1.4 million current cocaine users aged 12 or older (SAMHSA, 2012). Further, morbidity and mortality directly associated with cocaine dependence, as well as risky sexual behavior and impulsivity often exhibited in this population lead to increased risk of HIV transmission. To date, there is no FDA approved medication for CocUD. The Administrative Core supports the overall center goal of testing new medications to meet this need.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54DA038999-01
Application #
8850508
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
2014-09-15
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Type
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Moeller, F Gerard; Cunningham, Kathryn A (2018) Innovative Therapeutic Intervention For Opioid Use Disorder. Neuropsychopharmacology 43:220-221
Conroy, Stacey C; Bjork, James M (2018) Death Ambivalence and Treatment Seeking: Suicidality in Opiate Addiction. Curr Treat Options Psychiatry 5:291-300
Johns, Sade E; Wang, Qin; Straub, Lisa K et al. (2018) Impulsivity and decision making in older and younger cocaine-dependent participants: A preliminary study. Am J Addict 27:557-559
Ma, Liangsuo; Steinberg, Joel L; Wang, Qin et al. (2017) A preliminary longitudinal study of white matter alteration in cocaine use disorder subjects. Drug Alcohol Depend 173:39-46
Neelakantan, Harshini; Holliday, Erica D; Fox, Robert G et al. (2017) Lorcaserin Suppresses Oxycodone Self-Administration and Relapse Vulnerability in Rats. ACS Chem Neurosci 8:1065-1073
Bjork, James M; Burroughs, Thomas K; Franke, Laura M et al. (2017) Rapid-Response Impulsivity Predicts Depression and Posttraumatic Stress Disorder Symptomatology at 1-Year Follow-Up in Blast-Exposed Service Members. Arch Phys Med Rehabil 98:1646-1651.e1
Azadeh, Shabnam; Hobbs, Brian P; Ma, Liangsuo et al. (2016) Integrative Bayesian analysis of neuroimaging-genetic data with application to cocaine dependence. Neuroimage 125:813-824
Bjork, James M; Burroughs, Thomas K; Franke, Laura M et al. (2016) Laboratory impulsivity and depression in blast-exposed military personnel with post-concussion syndrome. Psychiatry Res 246:321-325
Ramesh, Divya; Keyser-Marcus, Lori A; Ma, Liangsuo et al. (2015) Prevalence of traumatic brain injury in cocaine-dependent research volunteers. Am J Addict 24:341-7
Ma, Liangsuo; Steinberg, Joel L; Keyser-Marcus, Lori et al. (2015) Altered white matter in cocaine-dependent subjects with traumatic brain injury: A diffusion tensor imaging study. Drug Alcohol Depend 151:128-34

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