The overall goals of the Mayo Clinic Urology O'Brien Research Center are to develop new diagnostic strategies in order to accurately phenotype patients and thus apply improved individualized management strategies. We will pursue these goals via 4 interlinked multidisciplinary projects. Important and timely aims of the Mayo Clinic O'Brien Urology Research Center include: 1) Develop and validate a comprehensive low-dose stone-characterization exam using clinical dual-energy CT techniques in order to predict stone fragility, and to develop new CT methods capable of detecting the earliest possible precursor lesions. 2) Determine factors that produce NL precursor lesions including Randall's plaques and tubular plugs. 3) Define specific factors that increase the risk of kidney stones and their recurrence, and develop clinical prediction tools to help clinicians identify high-risk patients. 4) Define environmental and genetic factors that influence oxalate transport and crystallization in a novel high throughput Drosophila model. This proposal is highly responsive to the O'Brien Urology Research Center RFA bringing together truly multidisciplinary group of experienced clinicians and basic scientists to conduct translational research. Each project is multidisciplinary, and clinical, translational and basic research is each well represented. Further, all projects have clear clinical relevance and will impact our understanding of nephrolithiasis and our ability to care for patients. The Mayo Clinic has a unique collection of resources such as the Rochester Epidemiology Project;funded laboratories with expertise in genetics, proteomics and transport physiology;large patient volumes;and the CT Imaging Innovation Center which can be applied to this common yet understudied disorder. Through this O'Brien Center, existing clinical and basic science expertise in urology, nephrology, radiology, epidemiology, genetics and physiology will work in synergy to foster rapid progress.
Research completed via this O'Brien Urology Research Center will improve our ability to detect and monitor kidney stones, and increase knowledge of the biology of their development including the molecular mechanisms of oxalate transport. Studies will also address the epidemiology of kidney stones and factors that make them recur. Results will improve clinical care of patients with nephrolithiasis.
|Tang, Xiaojing; Bergstralh, Eric J; Mehta, Ramila A et al. (2015) Nephrocalcinosis is a risk factor for kidney failure in primary hyperoxaluria. Kidney Int 87:623-31|
|Lieske, John C; Mehta, Ramila A; Milliner, Dawn S et al. (2015) Kidney stones are common after bariatric surgery. Kidney Int 87:839-45|
|Cabrero, Pablo; Terhzaz, Selim; Romero, Michael F et al. (2014) Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis. Proc Natl Acad Sci U S A 111:14301-6|
|Lieske, John C; Turner, Stephen T; Edeh, Samuel N et al. (2014) Heritability of urinary traits that contribute to nephrolithiasis. Clin J Am Soc Nephrol 9:943-50|
|Tang, Xiaojing; Lieske, John C (2014) Acute and chronic kidney injury in nephrolithiasis. Curr Opin Nephrol Hypertens 23:385-90|
|Rodgers, Allen; Gauvin, Daniel; Edeh, Samuel et al. (2014) Sulfate but not thiosulfate reduces calculated and measured urinary ionized calcium and supersaturation: implications for the treatment of calcium renal stones. PLoS One 9:e103602|
|Meeusen, Jeffrey W; Lieske, John C (2014) Looking for a better creatinine. Clin Chem 60:1036-9|
|Lieske, John C (2014) New insights regarding the interrelationship of obesity, diet, physical activity, and kidney stones. J Am Soc Nephrol 25:211-2|
|Singh, Prince; Knoedler, John J; Krambeck, Amy E et al. (2014) Thiazide diuretic prophylaxis for kidney stones and the risk of diabetes mellitus. J Urol 192:1700-4|
|Jepperson, Maria A; Ibrahim, El-Sayed H; Taylor, Abby et al. (2014) Accuracy and efficiency of determining urinary calculi composition using dual-energy computed tomography compared with Hounsfield unit measurements for practicing physicians. Urology 84:561-4|
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