; Although state-of-the-art CT provides accurate sub-millimeter details of the size and location of renal stones and separation of uric acid and non-uric acid stones, current routine clinical image analysis does not provide a comprehensive tool to quantitatively assess stone composition, volume, morphology and fragility, or to detect precursor lesions and trace elements related to stone formation. We have demonstrated that the novel algorithms developed in our lab during the initial funding period of our first O'Brien Center grant are able to separate eight common types of renal stones into five groups in an anthropomorphic phantom under clinical conditions, and into four groups in patients. In patients, we demonstrated an overall accuracy of 79.1%. We have also demonstrated the ability to accurately measure stone volume and surface morphology. In Project 1 of the current proposal, we will develop and validate tools to quantify interior stone morphology and use our quantitative measurements of stone composition, volume, surface and interior morphology to predict stone fragility. Thus, CT imaging, which is the predominant clinical tool used to diagnose and stage renal stones, can provide a much richer source of important clinical and research information when dual-energy data are acquired and quantitative analysis techniques used. The Imaging Core will provide five key functions in support of this O'Brien Urology Cooperative Research Center. These functions will directly support Projects 1, 2, and 3, and may be of value for pilot projects initiated during later years of the Center's activities. Additionally, the functions may be of considerable value to extramural researchers in the field of nephrolithiasis, including 1) Dual-energy CT scanning of ex-vivo specimens or patients; 2) Dual-energy CT attenuation, volume and morphology analyses; 3) Spectral CT scanning of ex-vivo specimens; 4) Coordination of micro-CT scanning and fragility testing with Dr. Jim Williams;and 5) Coordination of neutron activation analysis with Dr. Xin Liu.

Public Health Relevance

The Imaging Core is equipped with state of the art CT scanning technology, image processing computers and algorithms. This core provides a rich opportunity for multi-disciplinary research and brings the tremendous advances in imaging science of the last decade into the field of Nephrolithiasis research. The mission of the Imaging Core is to provide comprehensive non-invasive assessment of renal stones.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54DK100227-01
Application #
8626072
Study Section
Special Emphasis Panel (ZDK1-GRB-9 (M2))
Project Start
Project End
Budget Start
2013-09-29
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$188,787
Indirect Cost
$54,771
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Rule, Andrew D; Kremers, Walter K (2016) What Is the Correct Approach for Comparing GFR by Different Methods across Levels of GFR? Clin J Am Soc Nephrol 11:1518-21
Leng, Shuai; Huang, Alice; Cardona, Juan Montoya et al. (2016) Dual-Energy CT for Quantification of Urinary Stone Composition in Mixed Stones: A Phantom Study. AJR Am J Roentgenol 207:321-9
Perinpam, Majuran; Ware, Erin B; Smith, Jennifer A et al. (2016) Key influence of sex on urine volume and osmolality. Biol Sex Differ 7:12
Jaeger, Christopher D; Rule, Andrew D; Mehta, Ramila A et al. (2016) Endoscopic and Pathologic Characterization of Papillary Architecture in Struvite Stone Formers. Urology 90:39-44
Landry, Greg M; Hirata, Taku; Anderson, Jacob B et al. (2016) Sulfate and thiosulfate inhibit oxalate transport via a dPrestin (Slc26a6)-dependent mechanism in an insect model of calcium oxalate nephrolithiasis. Am J Physiol Renal Physiol 310:F152-9
Haley, William E; Enders, Felicity T; Vaughan, Lisa E et al. (2016) Kidney Function After the First Kidney Stone Event. Mayo Clin Proc 91:1744-1752
Giesen, Callen; Lieske, John C (2016) The Influence of Processing and Storage Conditions on Renal Protein Biomarkers. Clin J Am Soc Nephrol :
Ferrero, Andrea; Montoya, Juan C; Vaughan, Lisa E et al. (2016) Quantitative Prediction of Stone Fragility From Routine Dual Energy CT: Ex vivo proof of Feasibility. Acad Radiol 23:1545-1552
Lieske, John C; Turner, Stephen T; Edeh, Samuel N et al. (2016) Heritability of dietary traits that contribute to nephrolithiasis in a cohort of adult sibships. J Nephrol 29:45-51
Cheungpasitporn, Wisit; Rossetti, Sandro; Friend, Keith et al. (2016) Treatment effect, adherence, and safety of high fluid intake for the prevention of incident and recurrent kidney stones: a systematic review and meta-analysis. J Nephrol 29:211-9

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