The Biostatistics/Epidemiology Core will be responsible for all statistical, data management, and epidemiological aspects of the Mayo Clinic Urology O'Brien Center research grant. It is expected to serve all major projects as well as pilot projects and will be staffed by members of the Divisions of Biomedical Statistics and Informatics and Epidemiology who have expertise in statistical analysis, data management, and study design. Further, the Core investigators have extensive experience in the applications of quantitative methods to urologic and kidney problems, including nephrolithiasis. The objectives of the Core are to 1) provide high quality consultation to project investigators regarding study design, data analysis and interpretation of results, 2) maintain and extend the existing Olmsted County kidney stone database, 3) develop additional high quality linkable databases and quality control procedures for O'Brien Center research grant studies , and 4) foster and develop junior faculty in the statistical and epidemiological approach to clinical questions in nephrolithiasis.

Public Health Relevance

The existence of the Biostatistics/Epidemiology Core will provide the O'Brien Center research grants with uniform and efficient plans for protocol design, data management, quality control, and statistical analysis. Further, Core investigators will have a broad view of the O'Brien Center research grant, which will allow them to identify potential new interdisciplinary hypotheses and projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54DK100227-01
Application #
8626074
Study Section
Special Emphasis Panel (ZDK1-GRB-9 (M2))
Project Start
Project End
Budget Start
2013-09-29
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$208,777
Indirect Cost
$77,471
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Tang, Xiaojing; Bergstralh, Eric J; Mehta, Ramila A et al. (2015) Nephrocalcinosis is a risk factor for kidney failure in primary hyperoxaluria. Kidney Int 87:623-31
Lieske, John C; Mehta, Ramila A; Milliner, Dawn S et al. (2015) Kidney stones are common after bariatric surgery. Kidney Int 87:839-45
Cabrero, Pablo; Terhzaz, Selim; Romero, Michael F et al. (2014) Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis. Proc Natl Acad Sci U S A 111:14301-6
Lieske, John C; Turner, Stephen T; Edeh, Samuel N et al. (2014) Heritability of urinary traits that contribute to nephrolithiasis. Clin J Am Soc Nephrol 9:943-50
Tang, Xiaojing; Lieske, John C (2014) Acute and chronic kidney injury in nephrolithiasis. Curr Opin Nephrol Hypertens 23:385-90
Rodgers, Allen; Gauvin, Daniel; Edeh, Samuel et al. (2014) Sulfate but not thiosulfate reduces calculated and measured urinary ionized calcium and supersaturation: implications for the treatment of calcium renal stones. PLoS One 9:e103602
Meeusen, Jeffrey W; Lieske, John C (2014) Looking for a better creatinine. Clin Chem 60:1036-9
Lieske, John C (2014) New insights regarding the interrelationship of obesity, diet, physical activity, and kidney stones. J Am Soc Nephrol 25:211-2
Singh, Prince; Knoedler, John J; Krambeck, Amy E et al. (2014) Thiazide diuretic prophylaxis for kidney stones and the risk of diabetes mellitus. J Urol 192:1700-4
Jepperson, Maria A; Ibrahim, El-Sayed H; Taylor, Abby et al. (2014) Accuracy and efficiency of determining urinary calculi composition using dual-energy computed tomography compared with Hounsfield unit measurements for practicing physicians. Urology 84:561-4

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