The Biostatistics/Epidemiology Core will be responsible for all statistical, data management, and epidemiological aspects of the Mayo Clinic Urology O'Brien Center research grant. It is expected to serve all major projects as well as pilot projects and will be staffed by members of the Divisions of Biomedical Statistics and Informatics and Epidemiology who have expertise in statistical analysis, data management, and study design. Further, the Core investigators have extensive experience in the applications of quantitative methods to urologic and kidney problems, including nephrolithiasis. The objectives of the Core are to 1) provide high quality consultation to project investigators regarding study design, data analysis and interpretation of results, 2) maintain and extend the existing Olmsted County kidney stone database, 3) develop additional high quality linkable databases and quality control procedures for O'Brien Center research grant studies , and 4) foster and develop junior faculty in the statistical and epidemiological approach to clinical questions in nephrolithiasis.

Public Health Relevance

The existence of the Biostatistics/Epidemiology Core will provide the O'Brien Center research grants with uniform and efficient plans for protocol design, data management, quality control, and statistical analysis. Further, Core investigators will have a broad view of the O'Brien Center research grant, which will allow them to identify potential new interdisciplinary hypotheses and projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54DK100227-01
Application #
8626074
Study Section
Special Emphasis Panel (ZDK1-GRB-9 (M2))
Project Start
Project End
Budget Start
2013-09-29
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$208,777
Indirect Cost
$77,471
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Rule, Andrew D; Kremers, Walter K (2016) What Is the Correct Approach for Comparing GFR by Different Methods across Levels of GFR? Clin J Am Soc Nephrol 11:1518-21
Leng, Shuai; Huang, Alice; Cardona, Juan Montoya et al. (2016) Dual-Energy CT for Quantification of Urinary Stone Composition in Mixed Stones: A Phantom Study. AJR Am J Roentgenol 207:321-9
Perinpam, Majuran; Ware, Erin B; Smith, Jennifer A et al. (2016) Key influence of sex on urine volume and osmolality. Biol Sex Differ 7:12
Jaeger, Christopher D; Rule, Andrew D; Mehta, Ramila A et al. (2016) Endoscopic and Pathologic Characterization of Papillary Architecture in Struvite Stone Formers. Urology 90:39-44
Landry, Greg M; Hirata, Taku; Anderson, Jacob B et al. (2016) Sulfate and thiosulfate inhibit oxalate transport via a dPrestin (Slc26a6)-dependent mechanism in an insect model of calcium oxalate nephrolithiasis. Am J Physiol Renal Physiol 310:F152-9
Haley, William E; Enders, Felicity T; Vaughan, Lisa E et al. (2016) Kidney Function After the First Kidney Stone Event. Mayo Clin Proc 91:1744-1752
Giesen, Callen; Lieske, John C (2016) The Influence of Processing and Storage Conditions on Renal Protein Biomarkers. Clin J Am Soc Nephrol :
Ferrero, Andrea; Montoya, Juan C; Vaughan, Lisa E et al. (2016) Quantitative Prediction of Stone Fragility From Routine Dual Energy CT: Ex vivo proof of Feasibility. Acad Radiol 23:1545-1552
Lieske, John C; Turner, Stephen T; Edeh, Samuel N et al. (2016) Heritability of dietary traits that contribute to nephrolithiasis in a cohort of adult sibships. J Nephrol 29:45-51
Cheungpasitporn, Wisit; Rossetti, Sandro; Friend, Keith et al. (2016) Treatment effect, adherence, and safety of high fluid intake for the prevention of incident and recurrent kidney stones: a systematic review and meta-analysis. J Nephrol 29:211-9

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