Abstract

Slc26a6 knockout results in altered gut oxalate secretion and stone formation. Two groups recently knocked out Slc26a6 in mice. With proximal tubule (PT) oxalate secretion knocked out, one might predict that mice would develop hypo-oxaluria. However, the findings are the opposite, i.e., the Slc26a6-/- mice have hyperoxaluria and CaOx stones. Decreased intestinal ox2- secretion was demonstrated in one model. These knockout animals could give us insight into the pathophysiology of ox^"""""""" stone-formation, however, there has been little additional insight in the past several vears from these mice because, in part, the experiments are slow-going (i.e.. Slc26a6(-/-) mouse generated in 2006).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54DK100227-02
Application #
8734912
Study Section
Special Emphasis Panel (ZDK1-GRB-9)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
$110,540
Indirect Cost
$31,193

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Franz, Marie C; Pujol-Giménez, Jonai; Montalbetti, Nicolas et al. (2018) Reassessment of the Transport Mechanism of the Human Zinc Transporter SLC39A2. Biochemistry 57:3976-3986
Lieske, John C (2018) Bariatric Surgery and Kidney Health. J Am Soc Nephrol 29:1085-1086
Moen, Taylor; Ferrero, Andrea; McCollough, Cynthia (2018) Robustness of Textural Features to Predict Stone Fragility Across Computed Tomography Acquisition and Reconstruction Parameters. Acad Radiol :
Abd El-Salam, Mohamed; Bastos, Jairo Kenupp; Han, Jing Jing et al. (2018) The Synthesized Plant Metabolite 3,4,5-Tri-O-Galloylquinic Acid Methyl Ester Inhibits Calcium Oxalate Crystal Growth in a Drosophila Model, Downregulates Renal Cell Surface Annexin A1 Expression, and Decreases Crystal Adhesion to Cells. J Med Chem 61:1609-1621
Sivaguru, Mayandi; Saw, Jessica J; Williams Jr, James C et al. (2018) Geobiology reveals how human kidney stones dissolve in vivo. Sci Rep 8:13731
Shah, Ronak Jagdeep; Lieske, John C (2018) Inching toward a Greater Understanding of Genetic Hypercalciuria: The Role of Claudins. Clin J Am Soc Nephrol 13:1460-1462
Ruetten, Hannah; Wegner, Kyle A; Romero, Michael F et al. (2018) Prostatic collagen architecture in neutered and intact canines. Prostate 78:839-848
Marcus, Roy P; Fletcher, Joel G; Ferrero, Andrea et al. (2018) Detection and Characterization of Renal Stones by Using Photon-Counting-based CT. Radiology 289:436-442
Ferrero, Andrea; Gutjahr, Ralf; Halaweish, Ahmed F et al. (2018) Characterization of Urinary Stone Composition by Use of Whole-body, Photon-counting Detector CT. Acad Radiol 25:1270-1276
Vaughan, Lisa E; Enders, Felicity T; Lieske, John C et al. (2018) Predictors of Symptomatic Kidney Stone Recurrence After the First and Subsequent Episodes. Mayo Clin Proc :

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