Slc26a6 knockout results in altered gut oxalate secretion and stone formation. Two groups recently knocked out Slc26a6 in mice. With proximal tubule (PT) oxalate secretion knocked out, one might predict that mice would develop hypo-oxaluria. However, the findings are the opposite, i.e., the Slc26a6-/- mice have hyperoxaluria and CaOx stones. Decreased intestinal ox2- secretion was demonstrated in one model. These knockout animals could give us insight into the pathophysiology of ox^" stone-formation, however, there has been little additional insight in the past several vears from these mice because, in part, the experiments are slow-going (i.e.. Slc26a6(-/-) mouse generated in 2006).

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54DK100227-02
Application #
8734912
Study Section
Special Emphasis Panel (ZDK1-GRB-9)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
$110,540
Indirect Cost
$31,193
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Tang, Xiaojing; Bergstralh, Eric J; Mehta, Ramila A et al. (2015) Nephrocalcinosis is a risk factor for kidney failure in primary hyperoxaluria. Kidney Int 87:623-31
Lieske, John C; Mehta, Ramila A; Milliner, Dawn S et al. (2015) Kidney stones are common after bariatric surgery. Kidney Int 87:839-45
Cabrero, Pablo; Terhzaz, Selim; Romero, Michael F et al. (2014) Chloride channels in stellate cells are essential for uniquely high secretion rates in neuropeptide-stimulated Drosophila diuresis. Proc Natl Acad Sci U S A 111:14301-6
Lieske, John C; Turner, Stephen T; Edeh, Samuel N et al. (2014) Heritability of urinary traits that contribute to nephrolithiasis. Clin J Am Soc Nephrol 9:943-50
Tang, Xiaojing; Lieske, John C (2014) Acute and chronic kidney injury in nephrolithiasis. Curr Opin Nephrol Hypertens 23:385-90
Rodgers, Allen; Gauvin, Daniel; Edeh, Samuel et al. (2014) Sulfate but not thiosulfate reduces calculated and measured urinary ionized calcium and supersaturation: implications for the treatment of calcium renal stones. PLoS One 9:e103602
Meeusen, Jeffrey W; Lieske, John C (2014) Looking for a better creatinine. Clin Chem 60:1036-9
Lieske, John C (2014) New insights regarding the interrelationship of obesity, diet, physical activity, and kidney stones. J Am Soc Nephrol 25:211-2
Singh, Prince; Knoedler, John J; Krambeck, Amy E et al. (2014) Thiazide diuretic prophylaxis for kidney stones and the risk of diabetes mellitus. J Urol 192:1700-4
Jepperson, Maria A; Ibrahim, El-Sayed H; Taylor, Abby et al. (2014) Accuracy and efficiency of determining urinary calculi composition using dual-energy computed tomography compared with Hounsfield unit measurements for practicing physicians. Urology 84:561-4

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