Slc26a6 knockout results in altered gut oxalate secretion and stone formation. Two groups recently knocked out Slc26a6 in mice. With proximal tubule (PT) oxalate secretion knocked out, one might predict that mice would develop hypo-oxaluria. However, the findings are the opposite, i.e., the Slc26a6-/- mice have hyperoxaluria and CaOx stones. Decreased intestinal ox2- secretion was demonstrated in one model. These knockout animals could give us insight into the pathophysiology of ox^"""""""" stone-formation, however, there has been little additional insight in the past several vears from these mice because, in part, the experiments are slow-going (i.e.. Slc26a6(-/-) mouse generated in 2006).

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54DK100227-02
Application #
8734912
Study Section
Special Emphasis Panel (ZDK1-GRB-9)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
$110,540
Indirect Cost
$31,193
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
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