This proposal brings together an experienced group of investigators with a long track record of productive collaboration to address a major problem in benign urology. Vesicoureteral reflux and urinary tract obstruction are common birth defects in humans and account for 20% chronic kidney failure in children. Kidney damage be due to intrinsic genetic abnormalities that impair both nephrogenesis and ureteric function, or may be linked to scarring associated with recurrent febrile UTIs. This Center will employ a multidisciplinary approach to address the origins of development defects and their complications in humans and mouse models. The Center consists of 3 research projects, 2 pilot projects and an administrative core. The administrative Core will build on the existing collaborative and cooperative culture between our investigators to develop further connections with other members of the research community at Columbia, identify emerging opportunities for collaboration with the Urology Community at large and invite outside talents to apply their expertise to important problems in genetic and developmental Urology. The Education and Opportunity Pool Programs will serve as a vehicle to promote institutional and community awareness of urologic diseases research and provide opportunities for new discoveries in this vitally important area of biomedical science. Furthermore, the Administrative Core will coordinate interactions of the Columbia O Brien Center with other NIDDK Research Centers in the Cooperative Research Centers Program, and ensure compliance with all collaborative responsibilities to the network.
The first aim i s to develop and maintain the vision and relevant goals of the Center and coordinate, manage, and integrate the Center components and activities.
The second Aim i s to Harmonize the activities of the Columbia O Brien Center, facilitate interactions between research projects and serve as a portal for information sharing; communicate and coordinate with other Urology research centers and the community. The 3rd aim is to Implement an Education Program focused on Pediatric and Developmental Urology and focus on outreach. The 4th aims is o develop the Opportunity Pool program as a mechanism for innovative pilot studies or collaborative projects with other NIDDK funded programs focused on urology and developmental biology.
Vesicoureteral reflux and urinary tract obstruction are common birth defects in humans and account for 20% chronic kidney failure in children. Our multidisciplinary approach to this problem aims to bring progress by clarifying pathogenesis, devising new methods for prevention and treatment, and improving physician education.
| Joseph, Diya B; Chandrashekar, Anoop S; Abler, Lisa L et al. (2018) In vivo replacement of damaged bladder urothelium by Wolffian duct epithelial cells. Proc Natl Acad Sci U S A 115:8394-8399 |
| Kiryluk, Krzysztof; Bomback, Andrew S; Cheng, Yim-Ling et al. (2018) Precision Medicine for Acute Kidney Injury (AKI): Redefining AKI by Agnostic Kidney Tissue Interrogation and Genetics. Semin Nephrol 38:40-51 |
| Park, Jihwan; Shrestha, Rojesh; Qiu, Chengxiang et al. (2018) Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease. Science 360:758-763 |
| Wang, Xueqiao; Zheng, Xiaoqing; Zhang, Juanlian et al. (2018) Physiological functions of ferroportin in the regulation of renal iron recycling and ischemic acute kidney injury. Am J Physiol Renal Physiol 315:F1042-F1057 |
| Sanna-Cherchi, Simone; Westland, Rik; Ghiggeri, Gian Marco et al. (2018) Genetic basis of human congenital anomalies of the kidney and urinary tract. J Clin Invest 128:4-15 |
| Sanna-Cherchi, Simone; Khan, Kamal; Westland, Rik et al. (2017) Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations. Am J Hum Genet 101:789-802 |
| Costanzo, Maria Rosa; Ronco, Claudio; Abraham, William T et al. (2017) Extracorporeal Ultrafiltration for Fluid Overload in Heart Failure: Current Status and Prospects for Further Research. J Am Coll Cardiol 69:2428-2445 |
| Lopez-Rivera, Esther; Liu, Yangfan P; Verbitsky, Miguel et al. (2017) Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. N Engl J Med 376:742-754 |
| Verbitsky, Miguel; Kogon, Amy J; Matheson, Matthew et al. (2017) Genomic Disorders and Neurocognitive Impairment in Pediatric CKD. J Am Soc Nephrol 28:2303-2309 |
| Werth, Max; Schmidt-Ott, Kai M; Leete, Thomas et al. (2017) Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts. Elife 6: |
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