Yale Cooperative Hematology Specialized Core Center (YCHSCC) The purpose of the Yale Cooperative Hematology Specialized Core Center is to facilitate and enhance hematology research by providing investigators access to state-of-the-art technologies via both performance and teaching-based approaches. Our unique focus is the application of emerging technologies to normal and perturbed hematopoiesis in an environment in which innovative technical advances are shared and positively leveraged for the advancement of hematologic research. The larger goal of the YCHSCC is to play a key role in the integrated program of hematologic diseases-related research support provided by other NIDDK Cooperative Hematology Specialized Core Centers by providing opportunities to engender increased interactions and collaborations with hematology investigators within Yale and at other institutions as well as to promote hematology research in early career scientists. In the YCHSCC, four Emerging Technology research cores, a Cell Preparation and Analysis Core, an Imaging Core, an Expression and Genomics Core, and an Animal Modeling Core provide hematology investigators access to and assistance with state-of-the art technologies. Detailed education and training programs are in place for each Emerging Technology Core. These cores also evaluate and optimize new and emerging technologies for potential hematology-based applications. A program for Core access is in place for both internal and external hematology investigators, as is a plan to facilitate access by early stage investigators. Infrastructure for te cores, with fee-based cost recovery systems in place for operation at budget neutrality, will be financially advantageous for investigators. An Enrichment Program provides opportunities for hematology investigators to enhance their scientific knowledge by facilitating the exchange of information in several forums including interactive technique sharing symposia, research in progress presentations, and trainee exchange programs. A Pilot and Feasibility Program promotes hematology research by supporting work of early career investigators, established investigators new to hematology, and established hematology investigators pursuing novel research objectives. An Administrative Core facilitates operations of the YCHSCC, including performing administrative, financial, and personnel-related functions. Education and training of hematology investigators are integral functions of the YCHSCC. Fully active, leveraging the rich environment of Yale University, an engaged, collaborative hematology research base, and expertise in emerging technologies, the YCHSCC will provide the hematology community significant opportunities to drive advances in research. The ultimate goal is to improve diagnosis, treatment, and prevention of hematologic disease.

Public Health Relevance

The purpose of the Yale Cooperative Hematology Specialized Core Center is to facilitate and enhance research in blood diseases by facilitating synergy between many different scientists both within Yale and at multiple academic institutions across the country. The Center will help these scientists by providing access to and training in state-of-the-art technologies. Our unique focus is the application of emerging technologies to better understand blood diseases. The center will play a key role in the integrated program of blood disease research supported by other Cooperative Hematology Specialized Core Centers by providing opportunities to increase interactions and collaborations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54DK106857-03S1
Application #
9544538
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Gossett, Daniel Robert
Project Start
2015-08-01
Project End
2020-07-31
Budget Start
2017-09-06
Budget End
2018-07-31
Support Year
3
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Yale University
Department
Pathology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Gupta, Abhishek K; Murthy, Tushar; Paul, Kiran V et al. (2018) Degenerate minigene library analysis enables identification of altered branch point utilization by mutant splicing factor 3B1 (SF3B1). Nucleic Acids Res :
Rahman, Nur-Taz; Schulz, Vincent P; Wang, Lin et al. (2018) MRTFA augments megakaryocyte maturation by enhancing the SRF regulatory axis. Blood Adv 2:2691-2703
Xavier-Ferrucio, Juliana; Krause, Diane S (2018) Concise Review: Bipotent Megakaryocytic-Erythroid Progenitors: Concepts and Controversies. Stem Cells 36:1138-1145
Xavier-Ferrucio, Juliana; Ricon, Lauremília; Vieira, Karla et al. (2018) Hematopoietic defects in response to reduced Arhgap21. Stem Cell Res 26:17-27
Ricciardi, Adele S; Bahal, Raman; Farrelly, James S et al. (2018) In utero nanoparticle delivery for site-specific genome editing. Nat Commun 9:2481
Liang, Yang; Tebaldi, Toma; Rejeski, Kai et al. (2018) SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells. Leukemia 32:2659-2671
Weinstein, Jason S; Laidlaw, Brian J; Lu, Yisi et al. (2018) STAT4 and T-bet control follicular helper T cell development in viral infections. J Exp Med 215:337-355
Glogowska, Edyta; Schneider, Eve R; Maksimova, Yelena et al. (2017) Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis. Blood 130:1845-1856
Pan, Wen; Zhu, Shu; Qu, Kun et al. (2017) The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression. Immunity 47:284-297.e5
Swartz, Kelsey L; Wood, Scott N; Murthy, Tushar et al. (2017) E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. Mol Cell Biol 37:

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