The multi-site PREDICT-HD consortium led by the University of lowa on eariy detection of Huntington's Disease (HD) uses multimodal image, genetic, and clinical data from a large population to formulate and test hypotheses about the evolution of chronic diseases in at-risk individuals. Eariy intervention with implantable drug delivery devices could revolutionize the treatment of HD, but there are attendant risks. The statistical models that result from the application of customized image analysis to the PREDICT-HD cohort will provide a basis for conducting clinical pharmaceutical trials with increased sensitivity both to improvements and adverse outcomes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54EB005149-09
Application #
8501012
Study Section
Special Emphasis Panel (ZRG1-BST-K)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
9
Fiscal Year
2013
Total Cost
$193,804
Indirect Cost
$1,013
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Torgerson, Carinna M; Irimia, Andrei; Goh, S Y Matthew et al. (2015) The DTI connectivity of the human claustrum. Hum Brain Mapp 36:827-38
Irimia, Andrei; Van Horn, John Darrell (2015) Epileptogenic focus localization in treatment-resistant post-traumatic epilepsy. J Clin Neurosci 22:627-31
Whitford, Thomas J; Kubicki, Marek; Pelavin, Paula E et al. (2015) Cingulum bundle integrity associated with delusions of control in schizophrenia: Preliminary evidence from diffusion-tensor tractography. Schizophr Res 161:36-41
Irimia, Andrei; Torgerson, Carinna M; Goh, S-Y Matthew et al. (2015) Statistical estimation of physiological brain age as a descriptor of senescence rate during adulthood. Brain Imaging Behav 9:678-89
Tauscher, Sebastian; Tokuda, Junichi; Schreiber, G√ľnter et al. (2015) OpenIGTLink interface for state control and visualisation of a robot for image-guided therapy systems. Int J Comput Assist Radiol Surg 10:285-92
Tilak, Gaurie; Tuncali, Kemal; Song, Sang-Eun et al. (2015) 3T MR-guided in-bore transperineal prostate biopsy: A comparison of robotic and manual needle-guidance templates. J Magn Reson Imaging 42:63-71
McGann, Christopher; Akoum, Nazem; Patel, Amit et al. (2014) Atrial fibrillation ablation outcome is predicted by left atrial remodeling on MRI. Circ Arrhythm Electrophysiol 7:23-30
Kim, Eun Young; Magnotta, Vincent A; Liu, Dawei et al. (2014) Stable Atlas-based Mapped Prior (STAMP) machine-learning segmentation for multicenter large-scale MRI data. Magn Reson Imaging 32:832-44
Liangjia Zhu; Yi Gao; Appia, Vikram et al. (2014) A complete system for automatic extraction of left ventricular myocardium from CT images using shape segmentation and contour evolution. IEEE Trans Image Process 23:1340-51
Liu, Sidong; Cai, Weidong; Wen, Lingfeng et al. (2014) Multi-Channel neurodegenerative pattern analysis and its application in Alzheimer's disease characterization. Comput Med Imaging Graph 38:436-44

Showing the most recent 10 out of 417 publications