Core 4: Training? ? Successful creation, distribution, and adoption of POC diagnostic technologies in LRS requires an integrated understanding of clinical, technical ? (lab based), business development and intellectual property management, acceptability, usability and ergonomics, developing-world advocacy, ? and marketing and distribution issues. Rarely do researchers in any one field have the capacity to understand and act upon information from each ? of these critical disciplines. Creating growth opportunities for individuals already engaged in the development and uptake of POC technologies ? is critical to improving the development and eventual success of new technologies.? ? PATH and the UW Departments of Global Health and of Laboratory Medicine will offer a four-tier progressive training program which will engage ? individuals with varied experience and backgrounds from the fields of assay and device development, clinical laboratories, and disease specialties. ? The Point-of-Care International Diagnostics Education Advancement (POC IDEA) training courses will create a networked group of researchers trained ? in state-of-the-art technology and challenges for global health in LRS. Individuals with this unique skill set will be more likely to develop ? technologies appropriate for use in LRS, thus expediting the transition from research to meaningful clinical use.? ? We will leverage our long-standing and ongoing global health activities at multiple sites in LRS to strengthen the didactic, laboratory, and ? field-based components of the POC IDEA training program. Local, national,and international notices of the program will attract high-quality ? applicants. Successful applicants will be those currently working on POC device and/or technology development in academia or industry or training? in a PhD graduate program in any area related to rapid test diagnostics. Training a diverse group of researchers can be difficult, but through ? the UW's similar International Training and Education for HIV (ITECH) training programs, we have shown repeatedly that interdisciplinary training ? does work.? ? The POC IDEA training system will be implemented in four progressive courses (Figure 10). Curriculum content will be managed by key UW professors ? and staff with significant input from PATH'S Diagnostic Development Team. Courses will be taught by UW professors and staff, PATH researchers, ? and recognized leaders in the field of clinical and laboratory medicine.? ? POC IDEA Course 1 will start with a select group of 30 researchers from diverse technology and clinical backgrounds from high- and LRS across the ? globe, including 10 participants from developing countries. Prior to arriving at the training site, participants will receive access to a web-based ? tutorial which will familiarize them with the basic principles of POC testing. Course 1 will be taught in Seattle and focus on clinical issues ? related to POC diagnostic tests, relevant diseases of importance, and the realities and circumstances of LRS.? ? Based on the capabilities and interests of participants in Course 1,10 applicants will be selected to participate in Course 2 (5 technology developers ? and 5 from developing countries). Course 2 will be a 3-week course taught in Seattle the following year giving participants advanced experience with ? epidemiology and clinicalissues related to STIs and HIV through the UW's well-established 2-week annual course Principles of Sexually Transmitted ? Diseases and HIV Research (http://depts.washinqton.edu/pshr/). The course has been offered since 1993 and is widely recognized as one of the best ? international STI/HIVtraining short courses, attracting over 100 pre- and post-doctoral and junior faculty participants per year from more than 30 ? countries. Although the work of the Center will go beyond tests for STIs and HIV, this course will provide information that is highly representative ? of the issues typical of diagnosis of other infectious diseases as well, and also provides modules dealing with management of opportunistic infections ? such as tuberculosis, malaria, and viral hepatitis. In addition, Course 2 participants will spend an additional week with hands-on laboratory training ? on state-of-the-art diagnostic methods at teaching laboratory facilities at the Washington State Public Health Laboratory, Shoreline, WA.? ? From the 20 technology developers participating in Courses 1 or 2, 4 to 6 applicants will be selected for participation in Course 3, a field-based ? clinical and user training. Course 3 offers the unique opportunity for technology developers to visit LRS to understand how new technologies can ? be integrated into the health system for a benefit to all. Participants will have opportunities to visit clinics, manufacturing facilities, policymakers, ? and patients.? ? One or two laboratory scientists from Course 3 will be selected to participate in Course 4: the Assay Development Fellowship. Fellows will spend ? up to 6 months gaining advanced assay development skills both in the PATH labs and the UW labs, followed by a 3-month period of distance mentorship upon ? returning home. Courses 3 and 4 are designed to impart valuable skills to researchers which will enable them to accelerate the movement of POC diagnostics ? from research and development to clinical use.? ? Courses will be repeated through the duration of the Center (Table 12). Over the 5-year period of the Center, 150 researchers will receive training on ? clinical aspects of POC testing. These skills are critical to the successful development and uptake of new technologies.
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