The long-term goals of our center include addressing the epidemics of STDs and HIV in the U.S. and in resource-poor settings by development and better use of Point-of-Care (POC) tests, so as to address health inequity and improve the sexual health of individuals Our specific aims are 1) Provide a Center administrative structure to ensure that the large, complex Center achieves its goals in a timely manner.2) Conduct integrated clinical needs assessments and health impact assessments from clinicians, end-users, and other appropriate stakeholders, with the anticipation to advance and inform the field of POC testing design, development, and utilization by disseminating this information to the technology development community.3) Collaborate with physical and biochemical scientists, computational scientists, and systems engineers on a) exploratory technology for prototype development projects and b) for testing of more mature POCTs to insure a logical progression of assays along a pipeline from the concept stage to the clinical testing stage. 4) To test mature POC assays in clinical situations and in resource poor countries in order to enhance use of POC tests in settings such as emergency departments, home testing and to advance clinical acceptance and use of such tests and thus improve health especially for those experiencing health disparities and inequities.5) Provide training to technology developers across various career levels on clinical and process issues as well as needs related to the development of POC devices in an iterative fashion, as well as provide training for scientists in resource poor settins and education of relevant stakeholders on the development and potential impact of POC technologies. These goals and aims will be accomplished by an effective administrative component, ascertaining needs of users of POC, training of scientists, funding scientists and engineers for development of prototype and mature POC technologies, and pilot testing and implementation of POC tests in diverse clinical settings, which will lead to the commercialization and use of POC tests for diagnosing STDs in order to improve the sexual health of individuals in the United States and the rest of the world.

Public Health Relevance

of this project to public health is that by use of Point-of Care tests to rapidly and accurately diagnose sexually transmitted diseases (STDs), the sexual health of individuals in both the U.S. and in resource poor settings through the world will be improved. Rapid diagnosis and prompt treatment will improve sexual health in the world and prevent the spread of these infectious diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54EB007958-07
Application #
8502253
Study Section
Special Emphasis Panel (ZEB1-OSR-D (M2))
Program Officer
Korte, Brenda
Project Start
2007-09-30
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
7
Fiscal Year
2013
Total Cost
$1,504,445
Indirect Cost
$446,020
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Crowell, Trevor A; Hardick, Justin; Lombardi, Kara et al. (2018) Asymptomatic lymphogranuloma venereum among Nigerian men who have sex with men. Sex Transm Infect 94:578-581
Pittman, Ellen; Purcell, Hillary; Dize, Laura et al. (2018) Acceptability and feasibility of self-sampling for the screening of sexually transmitted infections in cabana privacy shelters. Int J STD AIDS 29:461-465
Gaydos, Charlotte A (2018) Let's Take A ""Selfie"": Self-Collected Samples for Sexually Transmitted Infections. Sex Transm Dis 45:278-279
Ronda, Jocelyn; Gaydos, Charlotte A; Perin, Jamie et al. (2018) Does the Sex Risk Quiz Predict Mycoplasma genitalium Infection in Urban Adolescents and Young Adult Women? Sex Transm Dis 45:728-734
Melendez, Johan H; Hardick, Justin; Barnes, Mathilda et al. (2018) Molecular Characterization of Markers Associated With Antimicrobial Resistance in Neisseria gonorrhoeae Identified From Residual Clinical Samples. Sex Transm Dis 45:312-315
Chen, Liben; Shin, Dong Jin; Zheng, Shuyu et al. (2018) Direct-qPCR Assay for Coupled Identification and Antimicrobial Susceptibility Testing of Neisseria gonorrhoeae. ACS Infect Dis 4:1377-1384
Patel, Anuj V; Gaydos, Charlotte A; Jett-Goheen, Mary et al. (2018) Assessing association between IWantTheKit risk quiz tool and sexually transmitted infection positivity in male users for sexually transmitted infection screening. Int J STD AIDS 29:122-127
Shin, Dong Jin; Lewis, Mitra; Hsieh, Yu-Hsiang et al. (2018) Healthcare worker feedback on a prototype smartphone-based point-of-care test platform for use in episodic care. Point Care 17:63-65
Patel, Anuj V; Abrams, Samuel M; Gaydos, Charlotte A et al. (2018) Increasing HIV testing engagement through provision of home HIV self-testing kits for patients who decline testing in the emergency department: a pilot randomisation study. Sex Transm Infect :

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