Abstract

Our ENIGMA Consortium is a truly international consortium involving researchers from 20 countries and 125 institutions worldwide. The consortium is organized into (1) the largest imaging genomics effort in history, analyzing brain MRI scans from 26,000 individuals with genome-wide data, (2) technical experts in the mathematics of Big Data, and (3) 9 Working Groups on schizophrenia, bipolar disorder, depression, ADHD, autism, OCD, 22q, HIV, and addictions. The opportunities for training and dissemination - and the global reach of the ENIGMA project - lie at the heart of ENIGMA'S ultra-collaborative training efforts. ENIGMA spans imaging, genetics, medicine, and mathematics, with diverse opportunities for cross-disciplinary training for researchers at all levels, to advance Big Data science.
Aim 1. ENIGMA Scientist Exchange Program. This innovative program will train researchers to analyze Big Data, focusing on imaging and genomics.
Aim 2. International Summer School. Building on our experience hosting summer schools on mathematics in medical imaging for hundreds of students, our annual summer school will host around 100 students for 2 weeks. These lectures will be archived on a YouTube Channel to facilitate access and allow us to update content. Meeting venues will rotate annually for maximum reach.
Aim 3. Workshops for Novices in ENIGMA Themes, Big Data Science. These 1-day hands-on workshops offer training in tool use for people analyzing Big Data.
Aim 4. ENIGMA Challenges. Expert users will compete to solve technically tough problems (ENIGMA Challenges) using the Hackathon/MICCAI Challenge model - yielding a published proceedings of short papers.
Aim 5. ENIGMA Website and Portal to ENIGMA Tools (ENIGMA-Vis, SLEP) and Training Materials. We will offer a single portal (http://enigma.ini.usc.edu) to access (1) ENIGMA'S tools, protocols, and software, (2) web-based queries of gene effects on brain measures, via the ENIGMA-Vis tool, and (3) multimedia updates on discoveries across ENIGMA, papers, video tutorials, radio interviews, news, and publicity materials to interest trainees, visitors, and new participants.

Public Health Relevance

ENIGMA'S Worldwide Training Program draws on the expertise, infrastructure and sheer collaborative power of 125 institutions analyzing 9 major brain diseases with large-scale imaging and genomics. ENIGMA'S Training Program offers a Scientist Exchange Program with a global reach. We offer an International Summer School, Workshops for Novices, Competitive Challenges for Experts, and a dynamically updated website for open access to ENIGMA'S tools, protocols, software, and publicity materials for trainees and the general public.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54EB020403-01
Application #
8905094
Study Section
Special Emphasis Panel (ZRG1-BST-N (52))
Project Start
Project End
Budget Start
2014-09-29
Budget End
2015-05-31
Support Year
1
Fiscal Year
2014
Total Cost
$297,272
Indirect Cost
$114,419

  Institution

Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Ruggeri, Barbara; Macare, Christine; Stopponi, Serena et al. (2018) Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents. J Child Psychol Psychiatry 59:650-658
Couvy-Duchesne, Baptiste; Strike, Lachlan T; de Zubicaray, Greig I et al. (2018) Lingual Gyrus Surface Area Is Associated with Anxiety-Depression Severity in Young Adults: A Genetic Clustering Approach. eNeuro 5:
Wang, Qi; Guo, Lei; Thompson, Paul M et al. (2018) The Added Value of Diffusion-Weighted MRI-Derived Structural Connectome in Evaluating Mild Cognitive Impairment: A Multi-Cohort Validation1. J Alzheimers Dis 64:149-169
King, Joseph A; Frank, Guido K W; Thompson, Paul M et al. (2018) Structural Neuroimaging of Anorexia Nervosa: Future Directions in the Quest for Mechanisms Underlying Dynamic Alterations. Biol Psychiatry 83:224-234
Olsen, Alexander; Dennis, Emily L; Evensen, Kari Anne I et al. (2018) Preterm birth leads to hyper-reactive cognitive control processing and poor white matter organization in adulthood. Neuroimage 167:419-428
Humphreys, Kathryn L; Watts, Emily L; Dennis, Emily L et al. (2018) Stressful Life Events, ADHD Symptoms, and Brain Structure in Early Adolescence. J Abnorm Child Psychol :
D'Alberto, Nicholas; Chaarani, Bader; Orr, Catherine A et al. (2018) Individual differences in stop-related activity are inflated by the adaptive algorithm in the stop signal task. Hum Brain Mapp 39:3263-3276
O'Halloran, Laura; Cao, Zhipeng; Ruddy, Kathy et al. (2018) Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology. Neuroimage 169:395-406
Walton, E; Hibar, D P; van Erp, T G M et al. (2018) Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium. Psychol Med 48:82-94
Zhang, Jie; Tu, Yanshuai; Li, Qingyang et al. (2018) MULTI-TASK SPARSE SCREENING FOR PREDICTING FUTURE CLINICAL SCORES USING LONGITUDINAL CORTICAL THICKNESS MEASURES. Proc IEEE Int Symp Biomed Imaging 2018:1406-1410

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