The Administrative Core will oversee and monitor all aspects ofthe Program. Dr. White, as PI, will interact on a weekly (minimally), often daily, basis with the other Project Pls, including Drs. Day and Aganwal. He will meet daily with Ms. Cheatham to discuss all pressing matters regarding the program, including upcoming CounterACT meetings, progress reports, interactive meetings with collaborators, meetings of the Internal (lAC) and External Advisory Committees (EAC), implementation of any new directives/mandates from NIH program staff, development of new scientific initiatives within the program as a result of lAC and or EAC recommendations, preparation of responses to EAC recommendations, monitoring of the program's CounterACT website, monitoring the training and progress of sponsored pre-doctoral, postdoctoral, and junior faculty involved in the program in Denver and at collaborating sites. Likewise, he will make decisions and take actions to respond to any of these matters and any other upcoming deadlines relevant to the program. He will be involved, along with Drs. Day and Aganwal, in recmiting new personnel among academic trainees and technical staff. He will coordinate and facilitate collaborative interactions between the projects in Denver and with the offsite collaborators, and he will initiate new offsite collaborations as required by new scientific directions and recommendations by the EAC and NIH administrative staff. He will write and submit grant supplements and, if available, carry fonward requests in order to allow success towards these mandates. He will oversee the Quality Assurance program throughout the Denver CounterACT group, and, in particular, monitor progress of each Project towards its timely achievement of its milestones and the quality of the data documenting that progress. Finally, he will convene regular meetings ofthe project Pls and their trainees to discuss scientific progress. He will assist all members of the team in their preparation of presentations and posters for the annual CounterACT meeting and all regional and national scientific meetings where CounterACT program findings will be presented. He will also interact regularly with Dr. Robert Mason to discuss potential regular guest speakers in the biodefense area and to prepare an annual symposium day on chemical defense and biodefense for the Denver area. Finally, he will oversee industry interactions of the program, including regular review of agents showing potential for rescue of injury due to mustard and/or chlorine and their product development. He will interact with industry partners to try to assure continued progress toward development of products after they have left the pre-clinical arena of the proof-of-principle studies routinely included in the CounterACT program. These would include presentations to, and applications for, BARDA, DTRA, and other DoD-sponsored grants for GLP studies and eventual FDA approval. All of the above-described activities have been among the daily, or at least regular, activities of the Administrative Core during the last cycle.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54ES015678-08
Application #
8535761
Study Section
Special Emphasis Panel (ZRG1-MDCN-J)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
8
Fiscal Year
2013
Total Cost
$146,548
Indirect Cost
$65,797
Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Tewari-Singh, Neera; Agarwal, Rajesh (2016) Mustard vesicating agent-induced toxicity in the skin tissue and silibinin as a potential countermeasure. Ann N Y Acad Sci 1374:184-92
McElroy, Cameron S; Day, Brian J (2016) Antioxidants as potential medical countermeasures for chemical warfare agents and toxic industrial chemicals. Biochem Pharmacol 100:1-11
White, Carl W; Rancourt, Raymond C; Veress, Livia A (2016) Sulfur mustard inhalation: mechanisms of injury, alteration of coagulation, and fibrinolytic therapy. Ann N Y Acad Sci 1378:87-95
McElroy, Cameron S; Min, Elysia; Huang, Jie et al. (2016) From the Cover: Catalytic Antioxidant Rescue of Inhaled Sulfur Mustard Toxicity. Toxicol Sci 154:341-353
Houin, Paul R; Veress, Livia A; Rancourt, Raymond C et al. (2015) Intratracheal heparin improves plastic bronchitis due to sulfur mustard analog. Pediatr Pulmonol 50:118-26
Ahmad, Shama; Ahmad, Aftab; Hendry-Hofer, Tara B et al. (2015) Sarcoendoplasmic reticulum Ca(2+) ATPase. A critical target in chlorine inhalation-induced cardiotoxicity. Am J Respir Cell Mol Biol 52:492-502
Kumar, Dileep; Tewari-Singh, Neera; Agarwal, Chapla et al. (2015) Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators. Toxicol Lett 235:161-71
Goswami, Dinesh G; Kumar, Dileep; Tewari-Singh, Neera et al. (2015) Topical nitrogen mustard exposure causes systemic toxic effects in mice. Exp Toxicol Pathol 67:161-70
Veress, Livia A; Anderson, Dana R; Hendry-Hofer, Tara B et al. (2015) Airway tissue plasminogen activator prevents acute mortality due to lethal sulfur mustard inhalation. Toxicol Sci 143:178-84
Jain, Anil K; Tewari-Singh, Neera; Inturi, Swetha et al. (2015) Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin. Toxicol Appl Pharmacol 285:71-8

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