As per the stated goals ofthe CounterACT program, we have created an educational program to increase interest and participation in applied toxicological research related to chemical threats. Our program has provided short-term education for technicians, medical and graduate students, postdoctoral fellows, and independent investigators at the combined centers of National Jewish Medical and Research Center and the University of Colorado at Denver Health Sciences Center. Our seminar series has been promoted at the National Jewish Campus, UCDHSC campus. School of Pharmacy, and the University's Boulder and Denver campuses. Overall, the program has included up to 7 events per year. The featured speakers have included a broad spectrum of toxicologists, lung biologists, clinician-scientists, and specialists from the field of military medicine. Originally, we had planned a day-long symposium in the area of vesicants and chemical threats, but our colleagues at Lovelace, also in the U54 program, developed such an annual program in our region, and so our program staff from NINDS discouraged us from duplicating that effort. We have now re-oriented our annual planned symposium day to place emphasis on inhalation injuries, chemical treats, airways injury and lung biology relevant to these areas. A tentative outline of the Symposium Day for the first year of the next cycle is attached.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZRG1-MDCN-J)
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University of Colorado Denver
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Tewari-Singh, Neera; Agarwal, Rajesh (2016) Mustard vesicating agent-induced toxicity in the skin tissue and silibinin as a potential countermeasure. Ann N Y Acad Sci 1374:184-92
McElroy, Cameron S; Day, Brian J (2016) Antioxidants as potential medical countermeasures for chemical warfare agents and toxic industrial chemicals. Biochem Pharmacol 100:1-11
White, Carl W; Rancourt, Raymond C; Veress, Livia A (2016) Sulfur mustard inhalation: mechanisms of injury, alteration of coagulation, and fibrinolytic therapy. Ann N Y Acad Sci 1378:87-95
McElroy, Cameron S; Min, Elysia; Huang, Jie et al. (2016) From the Cover: Catalytic Antioxidant Rescue of Inhaled Sulfur Mustard Toxicity. Toxicol Sci 154:341-353
Houin, Paul R; Veress, Livia A; Rancourt, Raymond C et al. (2015) Intratracheal heparin improves plastic bronchitis due to sulfur mustard analog. Pediatr Pulmonol 50:118-26
Ahmad, Shama; Ahmad, Aftab; Hendry-Hofer, Tara B et al. (2015) Sarcoendoplasmic reticulum Ca(2+) ATPase. A critical target in chlorine inhalation-induced cardiotoxicity. Am J Respir Cell Mol Biol 52:492-502
Kumar, Dileep; Tewari-Singh, Neera; Agarwal, Chapla et al. (2015) Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators. Toxicol Lett 235:161-71
Goswami, Dinesh G; Kumar, Dileep; Tewari-Singh, Neera et al. (2015) Topical nitrogen mustard exposure causes systemic toxic effects in mice. Exp Toxicol Pathol 67:161-70
Veress, Livia A; Anderson, Dana R; Hendry-Hofer, Tara B et al. (2015) Airway tissue plasminogen activator prevents acute mortality due to lethal sulfur mustard inhalation. Toxicol Sci 143:178-84
Jain, Anil K; Tewari-Singh, Neera; Inturi, Swetha et al. (2015) Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin. Toxicol Appl Pharmacol 285:71-8

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