Simbios has been led by an active executive committee, consisting of Drs. Altman, Delp, Pande, and Schmidt. The core staff is located in a collaboratory space provided by the Clark Center for Biomedical Engineering and Science with 1,000 sq. ft. allocated for the personnel and projects associated with Simbios. The highlights of our administrative plan include: ? Continued co-leadership from Drs. Altman, Delp and Pande whose research interests range from protein mechanics to clinical applications. Dr. Altman is a practicing physician and expert in bioinformatics. Dr. Delp is a bioengineer and an expert in biomechanical modeling and simulation. Dr. Pande is a chemist and an expert in molecular dynamics simulation. ? Dr. Jeanette Schmidt serves as Director with scientific credentials in computer science research (algorithms and data structures), and experience in the management of large, collaborative projects at Incyte Pharmaceuticals and then Simbios. ? A set of core investigators made of Core leaders in computer science (Hanrahan), biomedical computation (Pande), biomedical science (Delp), software engineering (Sherman), dissemination (Ku) and administration (Schmidt &Altman) to assess and manage the research and deployment mission. ? Strong institutional support from Stanford (see """"""""Letters of Support: Administration""""""""), including generous allocations of space (Figure ES.10), student support funds, and seed research funds. ? A clear record of establishing a national network of investigators (Figure ES.1). The executive committee will monitor the progress of DBPs, select new DBPs and seed projects. It will coordinate communication with the NIH, other NCBC sites, all of our collaborating R01/R21 grants, as well as other parts of the national biomedical computing infrastructure.
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| Liu, Tianyun; Ish-Shalom, Shirbi; Torng, Wen et al. (2018) Biological and functional relevance of CASP predictions. Proteins 86 Suppl 1:374-386 |
| Rojas, Enrique R; Billings, Gabriel; Odermatt, Pascal D et al. (2018) The outer membrane is an essential load-bearing element in Gram-negative bacteria. Nature 559:617-621 |
| DeMers, Matthew S; Hicks, Jennifer L; Delp, Scott L (2017) Preparatory co-activation of the ankle muscles may prevent ankle inversion injuries. J Biomech 52:17-23 |
| Rojas, Enrique R; Huang, Kerwyn Casey; Theriot, Julie A (2017) Homeostatic Cell Growth Is Accomplished Mechanically through Membrane Tension Inhibition of Cell-Wall Synthesis. Cell Syst 5:578-590.e6 |
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| Araya, Carlos L; Cenik, Can; Reuter, Jason A et al. (2016) Identification of significantly mutated regions across cancer types highlights a rich landscape of functional molecular alterations. Nat Genet 48:117-25 |
| Meng, Yilin; Shukla, Diwakar; Pande, Vijay S et al. (2016) Transition path theory analysis of c-Src kinase activation. Proc Natl Acad Sci U S A 113:9193-8 |
| Uchida, Thomas K; Hicks, Jennifer L; Dembia, Christopher L et al. (2016) Stretching Your Energetic Budget: How Tendon Compliance Affects the Metabolic Cost of Running. PLoS One 11:e0150378 |
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