This proposal for a Pittsburgh MIDAS Center of Excellence (U54) builds upon our proven track record of productivity in the NIGMS Modeling of Infectious Disease Agent Study """"""""MIDAS"""""""" program. In that prior collaborative effort we successfully advanced both the theory and practice of epidemic modeling. We developed large scale agent-based simulations of a threatening avian influenza pandemic, used our models to evaluate potential epidemic control strategies, and advised the highest levels of the US Government and the WHO on public health policy. The senior investigators from our MIDAS team - Burke, Ferguson, and Epstein - constitute the nucleus of this proposed Center of Excellence. Research within the Center of Excellence is divided into seven project teams, each focusing on a specific component problem in computational modeling;all seven projects are complementary without duplication. Four of the projects (Parameters, Behavior, Evolution, and Environment) seek to model the dynamical processes and subprocesses of infectious disease epidemics, while three others (Decisions, Preparedness, Applied Modeling) seek to improve the utility of models in public health policy decision-making. A unique feature of this Center of Excellence is its exceptionally interdisciplinary character;there is vigorous participation of behavioral scientists, psychologists, lawyers, and public health practitioners, and there are strong collaborations with public health agencies at the county (Allegheny), state (Pennsylvania) and national (CDC) levels. Three cores (Administrative;Education, Training, &Outreach;Computing) provide support across the Center. Key personnel are drawn from the University of Pittsburgh, Carnegie Mellon University, the Pittsburgh Supercomputing Center, Johns Hopkins University, the Brookings Institution, and Imperial College, all outstanding research institutions. We are well positioned to provide continued leadership in the renewed MIDAS network, and we are deeply committed to collaborative research not only within our own Center of Excellence but across the entire MIDAS network structure.

Public Health Relevance

The mission ofthe Pittsburgh MIDAS Center of Excellence is to protect the United States of America and the global community against communicable infectious disease threats. We will do this by improving our nation's ability to predict potential epidemics, to devise strategies to prevent the emergence or re-emergence of pathogenic microbes, and to respond rapidly - when necessary - to mitigate the impact of a spreading epidemic.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZGM1-CBCB-5 (MI))
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Sheeley, Douglas
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University of Pittsburgh
Public Health & Prev Medicine
Schools of Public Health
United States
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Brownwright, Tenley K; Dodson, Zan M; van Panhuis, Willem G (2017) Spatial clustering of measles vaccination coverage among children in sub-Saharan Africa. BMC Public Health 17:957
Salje, Henrik; Lessler, Justin; Maljkovic Berry, Irina et al. (2017) Dengue diversity across spatial and temporal scales: Local structure and the effect of host population size. Science 355:1302-1306
Kirsch, Thomas D; Moseson, Heidi; Massaquoi, Moses et al. (2017) Impact of interventions and the incidence of ebola virus disease in Liberia-implications for future epidemics. Health Policy Plan 32:205-214
Grubaugh, Nathan D; Ladner, Jason T; Kraemer, Moritz U G et al. (2017) Genomic epidemiology reveals multiple introductions of Zika virus into the United States. Nature 546:401-405
Farrow, David C; Brooks, Logan C; Hyun, Sangwon et al. (2017) A human judgment approach to epidemiological forecasting. PLoS Comput Biol 13:e1005248
Grantz, Kyra H; Rane, Madhura S; Salje, Henrik et al. (2017) Reply to Shanks and Brundage: Many plausible mechanisms of pandemic mortality disparities. Proc Natl Acad Sci U S A 114:E3588-E3589
Clapham, Hannah E; Rodriguez-Barraquer, Isabel; Azman, Andrew S et al. (2016) Dengue Virus (DENV) Neutralizing Antibody Kinetics in Children After Symptomatic Primary and Postprimary DENV Infection. J Infect Dis 213:1428-35
Lessler, Justin; Ott, Cassandra T; Carcelen, Andrea C et al. (2016) Times to key events in Zika virus infection and implications for blood donation: a systematic review. Bull World Health Organ 94:841-849
Nisalak, Ananda; Clapham, Hannah E; Kalayanarooj, Siripen et al. (2016) Forty Years of Dengue Surveillance at a Tertiary Pediatric Hospital in Bangkok, Thailand, 1973-2012. Am J Trop Med Hyg 94:1342-7
Chhatwal, Jagpreet; Jayasuriya, Suren; Elbasha, Elamin H (2016) Changing Cycle Lengths in State-Transition Models: Challenges and Solutions. Med Decis Making 36:952-64

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