Project III: Accounting for Measured and Unmeasured Heterogeneity in Host Populations proposes a variety of studies to assess the contribution of host heterogeneity to model parameter estimation for infections with different transmission routes and creates models incorporating two key sources of such heterogeneity: virus interference and dose-response relationships.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54GM088558-06
Application #
8796418
Study Section
Special Emphasis Panel (ZGM1-BBCB-5 (MI))
Project Start
Project End
Budget Start
2014-09-20
Budget End
2015-08-31
Support Year
6
Fiscal Year
2014
Total Cost
$172,616
Indirect Cost
$65,733
Name
Harvard University
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Li, Li; Wong, Jessica Y; Wu, Peng et al. (2018) Heterogeneity in Estimates of the Impact of Influenza on Population Mortality: A Systematic Review. Am J Epidemiol 187:378-388
Mier-Y-Teran-Romero, Luis; Delorey, Mark J; Sejvar, James J et al. (2018) Guillain-Barré syndrome risk among individuals infected with Zika virus: a multi-country assessment. BMC Med 16:67
Arnold, Brian J; Gutmann, Michael U; Grad, Yonatan H et al. (2018) Weak Epistasis May Drive Adaptation in Recombining Bacteria. Genetics 208:1247-1260
Iuliano, A Danielle; Roguski, Katherine M; Chang, Howard H et al. (2018) Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. Lancet 391:1285-1300
Cowling, Benjamin J; Chui, Celine S L; Lim, Wey Wen et al. (2018) Use of influenza antivirals in patients hospitalized in Hong Kong, 2000-2015. PLoS One 13:e0190306
Kwok, Kin On; Read, Jonathan M; Tang, Arthur et al. (2018) A systematic review of transmission dynamic studies of methicillin-resistant Staphylococcus aureus in non-hospital residential facilities. BMC Infect Dis 18:188
Lewnard, Joseph A; Grad, Yonatan H (2018) Vaccine waning and mumps re-emergence in the United States. Sci Transl Med 10:
Tedijanto, Christine; Olesen, Scott W; Grad, Yonatan H et al. (2018) Estimating the proportion of bystander selection for antibiotic resistance among potentially pathogenic bacterial flora. Proc Natl Acad Sci U S A 115:E11988-E11995
Chang, Qiuzhi; Abuelaish, Izzeldin; Biber, Asaf et al. (2018) Genomic epidemiology of meticillin-resistant Staphylococcus aureus ST22 widespread in communities of the Gaza Strip, 2009. Euro Surveill 23:
Choi, Horace C W; Jit, Mark; Leung, Gabriel M et al. (2018) Simultaneously characterizing the comparative economics of routine female adolescent nonavalent human papillomavirus (HPV) vaccination and assortativity of sexual mixing in Hong Kong Chinese: a modeling analysis. BMC Med 16:127

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