Project III: Accounting for Measured and Unmeasured Heterogeneity in Host Populations proposes a variety of studies to assess the contribution of host heterogeneity to model parameter estimation for infections with different transmission routes and creates models incorporating two key sources of such heterogeneity: virus interference and dose-response relationships.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54GM088558-07
Application #
8930710
Study Section
Special Emphasis Panel (ZGM1-BBCB-5)
Project Start
Project End
Budget Start
2015-09-01
Budget End
2016-08-31
Support Year
7
Fiscal Year
2015
Total Cost
$155,355
Indirect Cost
$59,160
Name
Harvard University
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02115
Cobey, Sarah; Baskerville, Edward B; Colijn, Caroline et al. (2017) Host population structure and treatment frequency maintain balancing selection on drug resistance. J R Soc Interface 14:
Eyal, Nir; Lipsitch, Marc (2017) Vaccine testing for emerging infections: the case for individual randomisation. J Med Ethics 43:625-631
Feng, Shuo; Fowlkes, Ashley L; Steffens, Andrea et al. (2017) Assessment of Virus Interference in a Test-negative Study of Influenza Vaccine Effectiveness. Epidemiology 28:514-524
Buckee, Caroline O; Tatem, Andrew J; Metcalf, C Jessica E (2017) Seasonal Population Movements and the Surveillance and Control of Infectious Diseases. Trends Parasitol 33:10-20
Wesolowski, Amy; Zu Erbach-Schoenberg, Elisabeth; Tatem, Andrew J et al. (2017) Multinational patterns of seasonal asymmetry in human movement influence infectious disease dynamics. Nat Commun 8:2069
Halloran, M Elizabeth; Auranen, Kari; Baird, Sarah et al. (2017) Simulations for designing and interpreting intervention trials in infectious diseases. BMC Med 15:223
Worby, Colin J; Wallinga, Jacco; Lipsitch, Marc et al. (2017) Population effect of influenza vaccination under co-circulation of non-vaccine variants and the case for a bivalent A/H3N2 vaccine component. Epidemics 19:74-82
Kraemer, Moritz U G; Faria, Nuno R; Reiner Jr, Robert C et al. (2017) Spread of yellow fever virus outbreak in Angola and the Democratic Republic of the Congo 2015-16: a modelling study. Lancet Infect Dis 17:330-338
Nathavitharana, Ruvandhi R; Shi, Cynthia X; Chindelevitch, Leonid et al. (2017) Polyclonal Pulmonary Tuberculosis Infections and Risk for Multidrug Resistance, Lima, Peru. Emerg Infect Dis 23:1887-1890
Andam, Cheryl P; Worby, Colin J; Gierke, Ryan et al. (2017) Penicillin Resistance of Nonvaccine Type Pneumococcus before and after PCV13 Introduction, United States. Emerg Infect Dis 23:1012-1015

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