Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54GM094585-05
Application #
8692869
Study Section
Special Emphasis Panel (ZGM1-CBB-4)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
5
Fiscal Year
2014
Total Cost
$778,583
Indirect Cost
$47,083
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Chang, Chin-Yuan; Lohman, Jeremy R; Huang, Tingting et al. (2018) Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027. Biochemistry 57:3278-3288
Chang, Chin-Yuan; Yan, Xiaohui; Crnovcic, Ivana et al. (2018) Resistance to Enediyne Antitumor Antibiotics by Sequestration. Cell Chem Biol 25:1075-1085.e4
van den Bosch, Tijs J M; Tan, Kemin; Joachimiak, Andrzej et al. (2018) Functional profiling and crystal structures of isothiocyanate hydrolases found in gut-associated and plant pathogenic bacteria. Appl Environ Microbiol :
Quaile, Andrew T; Stogios, Peter J; Egorova, Olga et al. (2018) The Legionella pneumophila effector Ceg4 is a phosphotyrosine phosphatase that attenuates activation of eukaryotic MAPK pathways. J Biol Chem 293:3307-3320
Xu, Li; Gordon, Ryan; Farmer, Rebecca et al. (2018) Precision therapeutic targeting of human cancer cell motility. Nat Commun 9:2454
Wang, Nan; Rudolf, Jeffrey D; Dong, Liao-Bin et al. (2018) Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme. Nat Chem Biol 14:730-737
Michalska, Karolina; Quan Nhan, Dinh; Willett, Julia L E et al. (2018) Functional plasticity of antibacterial EndoU toxins. Mol Microbiol 109:509-527
Kryshtafovych, Andriy; Albrecht, Reinhard; Baslé, Arnaud et al. (2018) Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016). Proteins 86 Suppl 1:27-50
Juárez-Vázquez, Ana Lilia; Edirisinghe, Janaka N; Verduzco-Castro, Ernesto A et al. (2017) Evolution of substrate specificity in a retained enzyme driven by gene loss. Elife 6:
Annaval, Thibault; Rudolf, Jeffrey D; Chang, Chin-Yuan et al. (2017) Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis. ACS Omega 2:5159-5169

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