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The major goal of the Center for Membrane Proteins in Infectious Diseases is to determine structures of membrane proteins involved in pathogenesis. The focus is on medically important viral and bacterial membrane proteins and human membrane proteins involved in their pathogenic pathways. The Center uses the biological theme of infectious diseases as the basis for the determination of novel membrane protein structures and to develop new technologies for high throughput membrane protein expression, isolation, functional characterization, crystallization and structure determination.

National Institute of Health (NIH)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZGM1)
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Arizona State University-Tempe Campus
United States
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Bolia, Ashini; Gerek, Z Nevin; Ozkan, S Banu (2014) BP-Dock: a flexible docking scheme for exploring protein-ligand interactions based on unbound structures. J Chem Inf Model 54:913-25
Martin-Garcia, Jose M; Hansen, Debra T; Zook, James et al. (2014) Purification and biophysical characterization of the CapA membrane protein FTT0807 from Francisella tularensis. Biochemistry 53:1958-70
Kupitz, Christopher; Grotjohann, Ingo; Conrad, Chelsie E et al. (2014) Microcrystallization techniques for serial femtosecond crystallography using photosystem II from Thermosynechococcus elongatus as a model system. Philos Trans R Soc Lond B Biol Sci 369:20130316
Boland, CoilĂ­n; Li, Dianfan; Shah, Syed Tasadaque Ali et al. (2014) Cell-free expression and in meso crystallisation of an integral membrane kinase for structure determination. Cell Mol Life Sci 71:4895-910
Li, Dianfan; Caffrey, Martin (2014) Renaturing membrane proteins in the lipid cubic phase, a nanoporous membrane mimetic. Sci Rep 4:5806
Nji, Emmanuel; Li, Dianfan; Doyle, Declan A et al. (2014) Cloning, expression, purification, crystallization and preliminary X-ray diffraction of a lysine-specific permease from Pseudomonas aeruginosa. Acta Crystallogr F Struct Biol Commun 70:1362-7
Domingo Meza-Aguilar, J; Fromme, Petra; Torres-Larios, Alfredo et al. (2014) X-ray crystal structure of the passenger domain of plasmid encoded toxin(Pet), an autotransporter enterotoxin from enteroaggregative Escherichia coli (EAEC). Biochem Biophys Res Commun 445:439-44
Caffrey, Martin; Li, Dianfan; Howe, Nicole et al. (2014) 'Hit and run' serial femtosecond crystallography of a membrane kinase in the lipid cubic phase. Philos Trans R Soc Lond B Biol Sci 369:20130621
Tan, Jingquan; Rouse, Sarah L; Li, Dianfan et al. (2014) A conformational landscape for alginate secretion across the outer membrane of Pseudomonas aeruginosa. Acta Crystallogr D Biol Crystallogr 70:2054-68
Li, Dianfan; Howe, Nicole; Dukkipati, Abhiram et al. (2014) Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy. Cryst Growth Des 14:2034-2047

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