Public Health Relevance

The major goal of the Center for Membrane Proteins in Infectious Diseases is to determine structures of membrane proteins involved in pathogenesis. The focus is on medically important viral and bacterial membrane proteins and human membrane proteins involved in their pathogenic pathways. The Center uses the biological theme of infectious diseases as the basis for the determination of novel membrane protein structures and to develop new technologies for high throughput membrane protein expression, isolation, functional characterization, crystallization and structure determination.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54GM094599-05
Application #
8692905
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Arizona State University-Tempe Campus
Department
Type
DUNS #
City
Tempe
State
AZ
Country
United States
Zip Code
Woodrum, Brian W; Maxwell, Jason; Allen, Denysia M et al. (2016) A Designed ""Nested"" Dimer of Cyanovirin-N Increases Antiviral Activity. Viruses 8:
Hansen, Debra T; Robida, Mark D; Craciunescu, Felicia M et al. (2016) Polyclonal Antibody Production for Membrane Proteins via Genetic Immunization. Sci Rep 6:21925
Batyuk, Alexander; Galli, Lorenzo; Ishchenko, Andrii et al. (2016) Native phasing of x-ray free-electron laser data for a G protein-coupled receptor. Sci Adv 2:e1600292
Zhou, X Edward; Gao, Xiang; Barty, Anton et al. (2016) X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex. Sci Data 3:160021
Munke, Anna; Andreasson, Jakob; Aquila, Andrew et al. (2016) Coherent diffraction of single Rice Dwarf virus particles using hard X-rays at the Linac Coherent Light Source. Sci Data 3:160064
Rowe, Timothy B; Luo, Zhe-Xi; Ketcham, Richard A et al. (2016) X-ray computed tomography datasets for forensic analysis of vertebrate fossils. Sci Data 3:160040
Coe, Jesse; Fromme, Petra (2016) Serial femtosecond crystallography opens new avenues for Structural Biology. Protein Pept Lett 23:255-72
Ayyer, Kartik; Yefanov, Oleksandr M; Oberthür, Dominik et al. (2016) Macromolecular diffractive imaging using imperfect crystals. Nature 530:202-6
Li, Dianfan; Stansfeld, Phillip J; Sansom, Mark S P et al. (2015) Ternary structure reveals mechanism of a membrane diacylglycerol kinase. Nat Commun 6:10140
Kang, Yanyong; Zhou, X Edward; Gao, Xiang et al. (2015) Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature 523:561-7

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