Public Health Relevance

The major goal of the Center for Membrane Proteins in Infectious Diseases is to determine structures of membrane proteins involved in pathogenesis. The focus is on medically important viral and bacterial membrane proteins and human membrane proteins involved in their pathogenic pathways. The Center uses the biological theme of infectious diseases as the basis for the determination of novel membrane protein structures and to develop new technologies for high throughput membrane protein expression, isolation, functional characterization, crystallization and structure determination.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54GM094599-05
Application #
8692905
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Arizona State University-Tempe Campus
Department
Type
DUNS #
City
Tempe
State
AZ
Country
United States
Zip Code
Hansen, Debra T; Craciunescu, Felicia M; Fromme, Petra et al. (2018) Generation of High-Specificity Antibodies against Membrane Proteins Using DNA-Gold Micronanoplexes for Gene Gun Immunization. Curr Protoc Protein Sci 91:29.20.1-29.20.22
Li, Xuanxuan; Chiu, Chun-Ya; Wang, Hsiang-Ju et al. (2017) Diffraction data of core-shell nanoparticles from an X-ray free electron laser. Sci Data 4:170048
Coe, Jesse; Fromme, Petra (2016) Serial femtosecond crystallography opens new avenues for Structural Biology. Protein Pept Lett 23:255-72
Hansen, Debra T; Robida, Mark D; Craciunescu, Felicia M et al. (2016) Polyclonal Antibody Production for Membrane Proteins via Genetic Immunization. Sci Rep 6:21925
Dörner, Katerina; Martin-Garcia, Jose M; Kupitz, Christopher et al. (2016) Characterization of Protein Nanocrystals Based on the Reversibility of Crystallization. Cryst Growth Des 16:3838-3845
Batyuk, Alexander; Galli, Lorenzo; Ishchenko, Andrii et al. (2016) Native phasing of x-ray free-electron laser data for a G protein-coupled receptor. Sci Adv 2:e1600292
Rowe, Timothy B; Luo, Zhe-Xi; Ketcham, Richard A et al. (2016) X-ray computed tomography datasets for forensic analysis of vertebrate fossils. Sci Data 3:160040
Lawrence, Robert M; Zook, James D; Hogue, Brenda G (2016) Full inactivation of alphaviruses in single particle and crystallized forms. J Virol Methods 236:237-244
Ayyer, Kartik; Yefanov, Oleksandr M; Oberthür, Dominik et al. (2016) Macromolecular diffractive imaging using imperfect crystals. Nature 530:202-6
Munke, Anna; Andreasson, Jakob; Aquila, Andrew et al. (2016) Coherent diffraction of single Rice Dwarf virus particles using hard X-rays at the Linac Coherent Light Source. Sci Data 3:160064

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