DATA SCIENCE RESEARCH BACKGROUND AND SIGNIFICANCE Biology in the 21st century has emerged as a "big data" science on par with physics or astronomy. Beginning with the landmark sequencing projects over a decade ago [1, 2], there have been successive waves of technological breakthroughs in probing cellular information on a genome-wide scale: microarrays , next generation sequencing , large-scale proteomics  and their many derivatives [6, 7]. Quick and widespread adoption of high throughput technologies has created massive amounts of data, yet there is a consensus that the floodgates have only barely opened . The explosive growth of data volume has fostered intense research in the development of informatics tools to store, manage and analyze such data . However, the scale and efficiency of the analysis is lagging behind the generation of data, a fact recognized by the major national funding agencies, with the result that the true potential of the data to accelerate biological discovery is not being realized. Analysis of biological data today is hampered by two major bottlenecks: (1) Integration: Different biotechnological tools record different kinds of cellular activities that provide complementary views of the same underlying biological phenomena. However, it has proved extremely difficult to integrate those partial descriptions into a well-organized whole, even though the advantages of such an integrative analysis of diverse data types are well recognized . (2) Scalability: The challenge of data integration is generally met with the most heavy-duty machine learning techniques of the day , which typically do not scale well with data size. Biology needs analysis tools that can handle the data deluge of its modern "omics" era. We propose to develop an E-science framework that will address the issues of integrative analysis and scalability associated with big data analysis in biology. We will build this environment from the ground up, laying its algorithmic foundations, engineering the scalable systems that form its skeleton frame, and creating the human-computer interface that makes it hospitable.