The Great Plains is a vast, rural region with pockets of urban development. Geographic and social isolation- combined with lack of access to primary and specialized care in both rural and underserved urban areas- characterizes some of our most vulnerable populations Our objective is to develop a robust, networked research infrastructure to nurture, develop, and guide our clinical and translational research (CTR) investigators, as well as build collaborations among them and with community members across the northern Great Plains. We plan to foster partnerships with other IDeA-CTR entities in order to share best practices on developing CTR undertakings. Such efforts will position us to become more competitive for research awards as we strive to better understand the development of disease and the means for its prevention-particularly as it pertains to rural and urban underserved populations in our IDeA-CTR network. The Great Plains IDeA- CTR will link the resources of the University of Nebraska Medical Center to those of its partners that stretch from Nebraska, to its neighboring IDeA states, South Dakota and North Dakota, and in collaboration with the University of Kansas Frontiers CTSA, to achieve four overall goals: 1) Create and sustain the infrastructure, services, resources, and community relationships needed to expand funded CTR; 2) Develop a cadre of successful CTR investigators with a comprehensive professional development program, pilot grants, key services (KCAs), and expertise, who are prepared to develop and implement innovative tools and approaches and lead CTR teams; 3) Build upon existing partnerships with regional Great Plains IDeA-CTR states of South Dakota, North Dakota, and Kansas to expand CTR teams, disseminate existing resources to enhance their utilization and reduce duplication, collaborate to build new programs and resources, and improve health outcomes; 4) Implement a comprehensive internal evaluation program to assess and strengthen Great Plains IDeA-CTR leadership, measure the impact of the Great Plains IDeA-CTR programs in the region, track Great Plains IDeA-CTR progress on goals and performance milestones, and assess effectiveness of resources and dissemination across the region.

Public Health Relevance

These goals will expand the infrastructure and CTR investigators prepared to design and conduct collaborative and innovative approaches to transform health delivery and outcomes. This initiative will improve health across the lifespan through innovative research, the highest quality patient care, outreach to underserved populations, and premier educational programs in the areas of mind, brain, and body health.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54GM115458-01
Application #
8947788
Study Section
Special Emphasis Panel (ZGM1-TWD-C (CT))
Program Officer
Gorospe, Rafael
Project Start
2016-09-01
Project End
2021-06-30
Budget Start
2016-09-01
Budget End
2017-06-30
Support Year
1
Fiscal Year
2016
Total Cost
$3,976,805
Indirect Cost
$1,159,884
Name
University of Nebraska Medical Center
Department
Neurology
Type
Schools of Medicine
DUNS #
168559177
City
Omaha
State
NE
Country
United States
Zip Code
68198
Smith, Lynette M; Gallagher, J Christopher; Suiter, Corinna (2017) Medium doses of daily vitamin D decrease falls and higher doses of daily vitamin D3 increase falls: A randomized clinical trial. J Steroid Biochem Mol Biol 173:317-322
Aksan, Nazan; Sager, Lauren; Hacker, Sarah et al. (2017) Individual differences in cognitive functioning predict effectiveness of a heads-up lane departure warning for younger and older drivers. Accid Anal Prev 99:171-183
Aksan, Nazan; Marini, Robert; Tippin, Jon et al. (2017) Effects of Actigraphically Acquired Sleep Quality onDriving Outcomes in Obstructive Sleep Apnea Patientsand Control drivers: A Naturalistic Study. Proc Int Driv Symp Hum Factors Driv Assess Train Veh Des 2017:242-250
Negi, Simarjeet K; Guda, Chittibabu (2017) Global gene expression profiling of healthy human brain and its application in studying neurological disorders. Sci Rep 7:897
Schwenzer, Anja; Quirke, Anne-Marie; Marzeda, Anna M et al. (2017) Association of Distinct Fine Specificities of Anti-Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis. Arthritis Rheumatol 69:2303-2313
England, Bryant R; Mikuls, Ted R; Xie, Fenglong et al. (2017) Herpes Zoster as a Risk Factor for Incident Giant Cell Arteritis. Arthritis Rheumatol 69:2351-2358
Estabrooks, Paul A (2017) Physical activity promotion and translational research. Transl Behav Med 7:1-2
Poole, Jill A; Mikuls, Ted R; Duryee, Michael J et al. (2017) A role for B cells in organic dust induced lung inflammation. Respir Res 18:214
Muir, Carlyn; Charlton, Judith L; Odell, Morris et al. (2016) Medical review licensing outcomes in drivers with visual field loss in Victoria, Australia. Clin Exp Optom 99:462-8
Aksan, Nazan; Hacker, Sarah D; Sager, Lauren et al. (2016) Correspondence between Simulator and On-Road Drive Performance: Implications for Assessment of Driving Safety. Geriatrics (Basel) 1:

Showing the most recent 10 out of 14 publications