The overall mission of the Administrative Core is to provide centralized and coordinated scientific, administrative, and financial management for the three Projects and the Human Ovary Tissue Bank within the Center to facilitate translation of basic research information to clinical application. Our major goals are to ensure appropriate decision-making processes between the Center (represented by the Directors) and the Internal Advisory Board, External Advisory Board, the NICHD Research Coordinator, and the Steering Committee of the Specialized Cooperative Centers in Reproduction and Infertility Research Program. We work to integrate and facilitate the scientific interactions of the Research Projects and the Human Ovary Tissue Bank and their scientific staff within the UCSD Center, as well as to facilitate research collaborations and interactions within the U54 Specialized Cooperative Centers in Reproduction and Infertility Research Program. The Administrative Core presents the Enrichment Program of international, national and local seminar speakers to elevate the profile of reproductive research in the scientific and clinical communities and to augment the many training programs in reproductive sciences at our Center including the WRHR program, the clinical fellowships in REI and Endocrine, the NIH T32 postdoc training in Reproductive Sciences, the graduate program in Biomedical Sciences, and undergraduate research programs. We organize scientific retreats, Steering Committee meetings, Internal and External Advisory Board meetings and visits, the Journal Club, Career hours, research meetings among the faculty and the trainees of the Center, and meetings of SCCPIR focus groups and Directors hosted in La Jolla. We serve as a focus to marshal institutional and community resources in support of reproductive research. The Administrative Core ensures appropriate access and efficient usage of the SCCPIR Human Ovary Tissue Bank. In addition, the Administrative Core supervises the application for release of the set-aside funds the Pilot and Collaborative Projects that support young investigators and collaborative, translational projects between our Center and SCCPIR Centers nationwide.

Public Health Relevance

The Administrative Core of the Center for Reproductive Science and Medicine provides many services to the Center including arranging meetings, seminars, journal clubs, and career guidance sessions. It facilitates interactions among the scientists at the Center and among the Centers nationwide. It facilitates the scientific training of many young individuals at a variety of levels of career advancement. Most importantly, encourages the translation of basic science to the bedside.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD012303-33
Application #
8446147
Study Section
Special Emphasis Panel (ZHD1-DSR-L)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
33
Fiscal Year
2013
Total Cost
$251,946
Indirect Cost
$121,279
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Fernandez, Marina O; Hsueh, Katherine; Park, Hyun Tae et al. (2017) Astrocyte-Specific Deletion of Peroxisome-Proliferator Activated Receptor-? Impairs Glucose Metabolism and Estrous Cycling in Female Mice. J Endocr Soc 1:1332-1350
Fernandez, Marina O; Sharma, Shweta; Kim, Sun et al. (2017) Obese Neuronal PPAR? Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility. Endocrinology 158:121-133
Tang, Kechun; Pasqua, Teresa; Biswas, Angshuman et al. (2017) Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice. J Endocrinol 232:137-153
Takahashi, Nozomi; Harada, Miyuki; Hirota, Yasushi et al. (2017) Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis. Sci Rep 7:10824
Homer, Michael V; Rosencrantz, Marcus A; Shayya, Rana F et al. (2017) The effect of estradiol on granulosa cell responses to FSH in women with polycystic ovary syndrome. Reprod Biol Endocrinol 15:13
Yamada-Nomoto, Kaori; Yoshino, Osamu; Akiyama, Ikumi et al. (2017) PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF-? and TNF-? in mononuclear cells by insulin-sensitizing drugs. Am J Reprod Immunol 78:
Hoffmann, Hanne M; Trang, Crystal; Gong, Ping et al. (2016) Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility. J Neurosci 36:3506-18
Baeza-Raja, Bernat; Sachs, Benjamin D; Li, Pingping et al. (2016) p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep 14:255-68
Kelley, Scott T; Skarra, Danalea V; Rivera, Alissa J et al. (2016) The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome. PLoS One 11:e0146509
Hoffmann, Hanne M; Mellon, Pamela L (2016) A small population of hypothalamic neurons govern fertility: the critical role of VAX1 in GnRH neuron development and fertility maintenance. Neurosci Commun (Houst) 2:

Showing the most recent 10 out of 257 publications