The Administration Core of the U54 Center """"""""Clinical and Basic Studies in PCOS"""""""" will have 3 main objectives. Firstly, it will promote and integrate reproduction related research at the University of Virginia, specifically the subprojects l-lll and pilot, the core laboratory and eligible grants in RSB program relevant areas. The Core also receives institutional resources to augment U54 Center activities, and actively facilitate interactions between basic and clinical investigators to allow rapid transfer of novel basic information to clinical applications. A second objective will be to facilitate research collaborations and interactions between investigators in the U54 Center at Virginia with those in other SCCPIR Centers. This goal will be achieved by regular communication with the Research Coordinator (RSB) and by attendance of the Program Director at the Center Director's and Focus group meetings. The latter provides insight into ongoing research in other Centers and allows forging of links between investigators at Virginia and other programs. Similarly, where Ligand core services offered in Virginia may benefit investigators in other Centers, they will be made available at minimal cost afforded by U54 support. The third objective will be to organize efficient core laboratory access for approved projects, to maintain accurate records of services provided and to effect appropriate chargeback for services rendered to eligible projects. New applications for access to U54 Ligand core services will be evaluated by the Core and if appropriate, forwarded to the Research Coordinator (RSB) for approval. Of particular import will be the role of the Core in promoting, facilitating and integrating research. The excellent collegial relationships between investigators at Virginia, which markedly enhance individual project productivity, will be fostered by provision of information on new developments and services from the U54 Center and by organizing monthly academic meetings to review ongoing research in Center projects. The Administration Core will review overall progress in the U54 Center. This will be achieved by regular meetings between the Program Director, the Director of Core laboratory and the Pis of Center subprojects, meetings of the Internal Advisory Committee and review by the External Advisory Committee.

Public Health Relevance

The Administration Core manages and facilitates reproductive research and development in four U54 subprojects. It also provides central support to ligand core that offers laboratory services and resources to scientists all over the USA. Its enrichment program (speaker seminar series) plays a major role in facilitating scientific information interchange between scientists in clinical and basic aspects of reproduction.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD028934-19
Application #
8375191
Study Section
Special Emphasis Panel (ZHD1-DSR-L)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
19
Fiscal Year
2012
Total Cost
$209,248
Indirect Cost
$75,939
Name
University of Virginia
Department
Type
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Patterson, Amanda L; George, Jitu W; Chatterjee, Anindita et al. (2018) Label-Retaining, Putative Mesenchymal Stem Cells Contribute to Myometrial Repair During Uterine Involution. Stem Cells Dev :
Greenwood, Eleni A; Pasch, Lauri A; Cedars, Marcelle I et al. (2018) Insulin resistance is associated with depression risk in polycystic ovary syndrome. Fertil Steril 110:27-34
Santos Guasch, Gabriela L; Beeler, J Scott; Marshall, Clayton B et al. (2018) p73 Is Required for Ovarian Follicle Development and Regulates a Gene Network Involved in Cell-to-Cell Adhesion. iScience 8:236-249
Jonak, Carrie R; Lainez, Nancy M; Boehm, Ulrich et al. (2018) GnRH Receptor Expression and Reproductive Function Depend on JUN in GnRH Receptor?Expressing Cells. Endocrinology 159:1496-1510
Sherman, Shermel B; Sarsour, Nadeen; Salehi, Marziyeh et al. (2018) Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis. Gut Microbes 9:400-421
Lainez, Nancy M; Jonak, Carrie R; Nair, Meera G et al. (2018) Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice. Front Immunol 9:1992
Klemp, Jennifer R; Myers, Jamie S; Fabian, Carol J et al. (2018) Cognitive functioning and quality of life following chemotherapy in pre- and peri-menopausal women with breast cancer. Support Care Cancer 26:575-583
Prins, Gail S; Ye, Shu-Hua; Birch, Lynn et al. (2017) Prostate Cancer Risk and DNA Methylation Signatures in Aging Rats following Developmental BPA Exposure: A Dose-Response Analysis. Environ Health Perspect 125:077007
Bu, Pengli; Yagi, Shintaro; Shiota, Kunio et al. (2017) Origin of a rapidly evolving homeostatic control system programming testis function. J Endocrinol 234:217-232
Gorsic, Lidija K; Kosova, Gulum; Werstein, Brian et al. (2017) Pathogenic Anti-Müllerian Hormone Variants in Polycystic Ovary Syndrome. J Clin Endocrinol Metab 102:2862-2872

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