The work proposed in this application is designed to increase our basic and clinical knowledge of reproductive processes in the male with particular relevance to male contraception. In addition to our four main projects, we also propose continuing our Administrative Core, which coordinates the management of the center, including fiscal management of the research projects and the development program of new invesfigators. This core provides administrative support for all center activities, including meetings and seminar series, and makes arrangements for visiting scientists and trainees. The core will be equally responsible to each project and will consist of a program manager and a fiscal specialist. These key individuals will work closely with personnel from the NICHD and campus administrators at the University of Washington, Washington State University and the Jackson Laboratories to manage study funding and regulatory approvals. The administrative core also coordinates the monthly seminar series, monthly investigators meetings and other meetings as necessary. In addition, this core will assure smooth functioning and excellent outcomes for our Fellows and New Investigators Program.
Our work is aimed at the development of new forms of contraception for men. This Administrative Core provides fiscal management and administrative assistance for the scientific projects, provides for training of new investigators in the field of contraceptive development, and coordinates meetings for dialogue between the scientists both within and from outside the center.
|Haenisch, Michael; Treuting, Piper M; Brabb, Thea et al. (2017) Pharmacological inhibition of ALDH1A enzymes suppresses weight gain in a mouse model of diet-induced obesity. Obes Res Clin Pract :|
|Ayoub, R; Page, S T; Swerdloff, R S et al. (2017) Comparison of the single dose pharmacokinetics, pharmacodynamics, and safety of two novel oral formulations of dimethandrolone undecanoate (DMAU): a potential oral, male contraceptive. Andrology 5:278-285|
|Thirumalai, Arthi; Rubinow, Katya B; Cooper, Lori A et al. (2017) Dose-response effects of sex hormone concentrations on body composition and adipokines in medically castrated healthy men administered graded doses of testosterone gel. Clin Endocrinol (Oxf) 87:59-67|
|Jing, Jing; Nelson, Cara; Paik, Jisun et al. (2017) Physiologically Based Pharmacokinetic Model of All-trans-Retinoic Acid with Application to Cancer Populations and Drug Interactions. J Pharmacol Exp Ther 361:246-258|
|Arnold, Samuel L; Stevison, Faith; Isoherranen, Nina (2016) Impact of Sample Matrix on Accuracy of Peptide Quantification: Assessment of Calibrator and Internal Standard Selection and Method Validation. Anal Chem 88:746-53|
|Roth, Mara Y; Amory, John K (2016) Beyond the Condom: Frontiers in Male Contraception. Semin Reprod Med 34:183-90|
|Kocarnik, Beverly M; Boyko, Edward J; Matsumoto, Alvin M et al. (2016) Baseline estradiol concentration in community-dwelling Japanese American men is not associated with intra-abdominal fat accumulation over 10 years. Obes Res Clin Pract 10:624-632|
|Chao, Jing; Rubinow, Katya B; Kratz, Mario et al. (2016) Short-Term Estrogen Withdrawal Increases Adiposity in Healthy Men. J Clin Endocrinol Metab 101:3724-3731|
|Griswold, Michael D (2016) Spermatogenesis: The Commitment to Meiosis. Physiol Rev 96:1-17|
|Roth, M Y; Page, S T; Bremner, W J (2016) Male hormonal contraception: looking back and moving forward. Andrology 4:4-12|
Showing the most recent 10 out of 118 publications