The work proposed in this application is designed to increase our basic and clinical knowledge of reproductive processes in the male with particular relevance to male contraception. In addition to our four main projects, we also propose continuing our Administrative Core, which coordinates the management of the center, including fiscal management of the research projects and the development program of new invesfigators. This core provides administrative support for all center activities, including meetings and seminar series, and makes arrangements for visiting scientists and trainees. The core will be equally responsible to each project and will consist of a program manager and a fiscal specialist. These key individuals will work closely with personnel from the NICHD and campus administrators at the University of Washington, Washington State University and the Jackson Laboratories to manage study funding and regulatory approvals. The administrative core also coordinates the monthly seminar series, monthly investigators meetings and other meetings as necessary. In addition, this core will assure smooth functioning and excellent outcomes for our Fellows and New Investigators Program.

Public Health Relevance

Our work is aimed at the development of new forms of contraception for men. This Administrative Core provides fiscal management and administrative assistance for the scientific projects, provides for training of new investigators in the field of contraceptive development, and coordinates meetings for dialogue between the scientists both within and from outside the center.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54HD042454-11
Application #
8400512
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
11
Fiscal Year
2012
Total Cost
$319,835
Indirect Cost
$112,822
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Berkseth, Kathryn E; Rubinow, Katya B; Melhorn, Susan J et al. (2018) Hypothalamic Gliosis by MRI and Visceral Fat Mass Negatively Correlate with Plasma Testosterone Concentrations in Healthy Men. Obesity (Silver Spring) 26:1898-1904
Rubinow, Katya B; Houston, Barbara; Wang, Shari et al. (2018) Androgen receptor deficiency in monocytes/macrophages does not alter adiposity or glucose homeostasis in male mice. Asian J Androl 20:276-283
Chen, Yan; Zhu, Jin-Yi; Hong, Kwon Ho et al. (2018) Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors. ACS Chem Biol 13:582-590
Paik, Jisun; Treuting, Piper M; Haenisch, Michael et al. (2018) Can inhibition of retinoic acid biosynthesis function as a non-hormonal female contraceptive? Contraception :
Sharma, Manju; Braun, Robert E (2018) Cyclical expression of GDNF is required for spermatogonial stem cell homeostasis. Development 145:
Rubinow, Katya B; Vaisar, Tomas; Chao, Jing H et al. (2018) Sex steroids mediate discrete effects on HDL cholesterol efflux capacity and particle concentration in healthy men. J Clin Lipidol 12:1072-1082
Haenisch, Michael; Treuting, Piper M; Brabb, Thea et al. (2018) Pharmacological inhibition of ALDH1A enzymes suppresses weight gain in a mouse model of diet-induced obesity. Obes Res Clin Pract 12:93-101
Swerdloff, Ronald S; Dudley, Robert E; Page, Stephanie T et al. (2017) Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels. Endocr Rev 38:220-254
Ayoub, R; Page, S T; Swerdloff, R S et al. (2017) Comparison of the single dose pharmacokinetics, pharmacodynamics, and safety of two novel oral formulations of dimethandrolone undecanoate (DMAU): a potential oral, male contraceptive. Andrology 5:278-285
Rubinow, Katya B; Chao, Jing H; Hagman, Derek et al. (2017) Circulating sex steroids coregulate adipose tissue immune cell populations in healthy men. Am J Physiol Endocrinol Metab 313:E528-E539

Showing the most recent 10 out of 129 publications